The Mechanisms of Drug Resistance of Acute Myeloid Leukemia Cells in Three-Dimensional High-Density Cultures: a Study of Intracellular Accumulation of Chemotherapeutic Drugs

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology

Biophysics Pub Date : 2026-01-14 DOI:10.1134/S0006350925700708

M. I. Kobyakova, Ya. V. Lomovskaya, R. S. Fadeev

引用次数: 0

Abstract

Intracellular accumulation of chemotherapeutic drugs in resistant cells of acute myeloid leukemia cultured in a three-dimensional high-density culture was studied. It was shown that neither the dense arrangement of cells nor the presence of the main ABC family transporter proteins most likely affects the increase in drug resistance of acute myeloid leukemia cells in a three-dimensional high-density cell culture. These data indicate the involvement of other mechanisms in increasing drug resistance in three-dimensional high-density cell cultures of acute myeloid leukemia.

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三维高密度培养急性髓系白血病细胞耐药机制：化疗药物在细胞内蓄积的研究

研究了三维高密度培养急性髓系白血病耐药细胞内化疗药物的蓄积。研究表明，在三维高密度细胞培养中，细胞的密集排列和主要ABC家族转运蛋白的存在都不太可能影响急性髓系白血病细胞耐药的增加。这些数据表明，在急性髓系白血病三维高密度细胞培养中，其他机制参与增加耐药性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.