Personality moderates the predictive value of serum serotonin for antidepressant remission in depressive disorders

IF 3.4 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology Pub Date : 2026-04-01 Epub Date: 2026-01-12 DOI:10.1016/j.psyneuen.2026.107752

Jae-Min Kim , Hee-Ju Kang , Ju-Wan Kim, Min Jhon, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin

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Abstract

Blood-based biomarkers such as peripheral serotonin (5-HT) hold promise for predicting antidepressant response in depression, but findings have been inconsistent. Personality traits linked to serotonergic function may moderate this relationship. This study examined whether personality type (PT) moderates the relationship between baseline serum serotonin (s5-HT) levels and antidepressant remission at 12 weeks. In a prospective, naturalistic study, 1086 outpatients with depressive disorders received stepwise pharmacotherapy. PT was classified as resilient or vulnerable using cluster analysis of the Big Five Inventory. Baseline s5-HT was measured and analyzed as both categorical (median split) and continuous variables. Remission was defined as a Hamilton Depression Rating Scale (HAMD) score ≤ 7 at week 12. Logistic regression tested the main and interaction effects of PT and s5-HT, adjusting for covariates. No direct association was found between PT and s5-HT levels. However, higher s5-HT significantly predicted remission only in the resilient group, showing a significant PT × s5-HT interaction. These findings identify personality as a moderator of the relationship between peripheral serotonin and antidepressant response. This biopsychosocial interaction may help explain prior inconsistencies and may provide preliminary insights relevant to individualized care, pending further validation.

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人格调节血清5 -羟色胺对抑郁症抗抑郁缓解的预测价值

基于血液的生物标志物，如外周血清素（5-HT）有望预测抑郁症的抗抑郁反应，但研究结果并不一致。与血清素功能相关的人格特征可能会缓和这种关系。本研究考察了人格类型（PT）是否调节基线血清5-羟色胺（5- ht）水平与12周抗抑郁缓解之间的关系。在一项前瞻性、自然主义研究中，1086名抑郁症门诊患者接受了分步药物治疗。使用五大库存的聚类分析将PT分类为弹性或脆弱。基线5- ht作为分类变量（中位数分割）和连续变量进行测量和分析。缓解的定义是汉密尔顿抑郁评定量表（HAMD）在第12周得分≤ 7。经协变量调整后，Logistic回归检验PT和5- ht的主效应和交互效应。没有发现PT和5- ht水平之间的直接关联。然而，较高的5- ht仅在弹性组中显著预测缓解，显示出显著的PT × 5- ht相互作用。这些发现表明，人格是外周血清素和抗抑郁反应之间关系的调节因素。这种生物心理社会相互作用可能有助于解释先前的不一致，并可能提供与个性化护理相关的初步见解，有待进一步验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychoneuroendocrinology 医学-精神病学

CiteScore

7.40

自引率

8.10%

发文量

268

审稿时长

66 days

期刊介绍： Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.