Magneto-photoelectrochemical 2D heterojunction platform for biosensing detection

IF 3.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical Pub Date : 2026-04-15 Epub Date: 2026-01-14 DOI:10.1016/j.snb.2026.139478

Tao Wang , Nan Zhang , Hongjie Huang , Yunhe An , Yunyun Dai , Yongrui Li , Nan Yang , Chaojie Yang , Xinran Zhou , Yucheng Zhu , Yingshan Ma , Lingling Huang , Yongtian Wang , Yang Liu , Zhiyong Yan

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引用次数: 0

Abstract

Photoelectrochemical (PEC) biosensors exhibit significant potential for biomolecule detection due to their high sensitivity and low background noise. However, their performance is severely constrained by the rapid recombination of photogenerated charge carriers. This study innovatively introduces a non-contact magnetic modulation strategy to suppress electron-hole recombination by manipulating carrier spin states, thereby significantly enhancing photoelectric conversion efficiency. Building on this mechanism, we developed a novel magnetically modulated PEC biosensing platform based on the MXenes/cobalt-doped titanium dioxide (Co-TiO₂) heterostructure. This platform achieved ultrasensitive detection of protein kinase A (PKA) activity. Compared to an identical probe-modified biosensor without magnetic field application, the developed platform demonstrated a 68.75 % enhancement in detection sensitivity and achieved an ultralow limit of detection for PKA of 0.00016 U/mL in the linear range of 0.005–80 U/mL. This research not only provides a novel methodology for kinase activity analysis but also pioneers the innovative strategy of magnetic modulation for enhanced PEC sensing. It opens new avenues for developing high-performance biosensing platforms, holding significant promise for early disease diagnosis and drug screening applications.

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磁光电化学二维异质结生物传感检测平台

光电化学（PEC）生物传感器具有高灵敏度和低背景噪声的特点，在生物分子检测领域具有重要的应用潜力。然而，它们的性能受到光生载流子快速重组的严重限制。本研究创新性地引入了一种非接触磁调制策略，通过操纵载流子自旋态来抑制电子-空穴复合，从而显著提高光电转换效率。基于这一机制，我们开发了一种基于MXenes/钴掺杂二氧化钛（Co-TiO2）异质结构的新型磁调制PEC生物传感平台。该平台实现了蛋白激酶A （PKA）活性的超灵敏检测。与未应用磁场的探针修饰生物传感器相比，该平台的检测灵敏度提高了68.75 %，在0.005-80 U/mL的线性范围内，PKA的超低检出限为0.00016 U/mL。这项研究不仅为激酶活性分析提供了一种新的方法，而且开创了磁调制增强PEC传感的创新策略。它为开发高性能生物传感平台开辟了新的途径，为早期疾病诊断和药物筛选应用带来了重大希望。

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来源期刊

Sensors and Actuators B: Chemical 工程技术-电化学

CiteScore

14.60

自引率

11.90%

发文量

1776

审稿时长

3.2 months

期刊介绍： Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.