Association of insulin therapy with diabetic retinopathy in type 2 diabetes: A cross-sectional analysis from the Beichen Eye Study

IF 2.7 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2026-02-01 Epub Date: 2026-01-10 DOI:10.1016/j.pdpdt.2026.105345

Jingyao Liu, Qianhui Yang, Juping Liu, Xiaorong Li

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引用次数: 0

Abstract

Purpose

To describe and investigate the associations between different glucose-lowering management and diabetic retinopathy (DR).

Methods

Our study was a cross-sectional analysis. By comparing different glucose-lowering management methods, we aim to explore their impact on the occurrence of diabetic retinopathy (DR) and their influence on its severity. Logistic regression models were used to estimate the odds ratio (OR).

Results

Through the Beichen Eye Study (BCES), 844 patients were included in the cross-sectional analysis. The prevalence of DR was 19.30% among patients on oral hypoglycemic agents (OHA), 50.00% on insulin treatment, and 37.12% among those on combined use, giving an overall frequency of 24.65%. No statistically significant differences were observed among different types of oral hypoglycemic agents on the incidence and severity of DR. Logistic regression showed insulin therapy was associated with the prevalence of DR [insulin: OR= 3.57 (95% CI: 1.16 ∼ 11.05), p= 0.027; combination: OR= 2.01 (95% CI: 1.39 ∼ 2.91), p< 0.001].

Conclusion

Compared with OHA, either increasing insulin therapy or using insulin alone can be a risk factor for DR, yet it has no impact on DR severity.

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胰岛素治疗与2型糖尿病视网膜病变的关系：来自北辰眼科研究的横断面分析

目的：描述和研究不同降糖管理与糖尿病视网膜病变（DR）之间的关系。方法：本研究采用横断面分析。通过比较不同的降糖管理方法，探讨其对糖尿病视网膜病变（DR）发生及严重程度的影响。采用Logistic回归模型估计比值比（OR）。结果：通过北辰眼科研究（BCES）， 844例患者被纳入横断面分析。口服降糖药（OHA）组DR发生率为19.30%，胰岛素组为50.00%，联合用药组为37.12%，总发生率为24.65%。不同类型口服降糖药对DR发病率和严重程度的影响无统计学差异。Logistic回归显示胰岛素治疗与DR患病率相关[胰岛素：OR= 3.57 (95% CI: 1.16 ~ 11.05), p= 0.027；组合：OR= 2.01 (95% CI: 1.39 ~ 2.91), p< 0.001)。结论：与OHA相比，增加胰岛素治疗或单独使用胰岛素都可能是DR的危险因素，但对DR的严重程度没有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.