Elucidating the mechanism of traditional Chinese medicine formula (Yifei-sanjie Pill) in alleviating the chemobrain based on network pharmacology and experimental verification

IF 3.9 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional and Complementary Medicine Pub Date : 2026-01-01 Epub Date: 2024-11-21 DOI:10.1016/j.jtcme.2024.11.008

Yingchao Wu , Hui Wang , Zheng Liang , Jiaqi Cui , Siyan Liu , Yiliu Chen , Dajin Pi , Mingzi Ouyang

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引用次数: 0

Abstract

Background

Cisplatin (DDP) is widely used to treat clinical malignant tumors, but it is also accompanied by serious adverse reactions, such as brain nervous system injury. In clinical treatment and animal experiments, traditional Chinese medicine formula (Yifei-sanjie Pill, YFSJ) has been observed to relieve the symptoms of chemobrain caused by DDP chemotherapy, but its mechanism of action remains unclear.

Methods

A subcutaneous model of non-small cell lung cancer was established in mice, which were subsequently treated with YFSJ to evaluate the mechanism by which YFSJ alleviates DDP-induced chemobrain. Specifically, the effects of DDP and YFSJ on the brain nervous system of mice were evaluated by behavioral tests, brain blood flow observation, network pharmacology analysis, and histological analysis. In addition, the damaging effect of DDP on neurons and the effect of YFSJ on neurons were verified by in vitro experiments.

Results

YFSJ reduced systemic inflammation in tumor-bearing mice, restored the function of the blood‒brain barrier (BBB) to reduce the amount of cisplatin in the brain, alleviated the decreases in voluntary activity and brain blood flow microcirculation induced by DDP, and alleviated brain tissue pyroptosis and ferroptosis caused by DDP.

Conclusions

YFSJ maintains the functional stability of the BBB by inhibiting tumor-induced inflammation, thereby preventing chemobrain induced by nervous system damage caused by DDP entering brain tissue.

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基于网络药理学和实验验证的益肺散结丸中药方剂缓解化学脑的作用机制

背景顺铂（DDP）被广泛应用于临床恶性肿瘤的治疗，但同时也伴随着严重的不良反应，如脑神经系统损伤。在临床治疗和动物实验中，中药复方益肺散结丸（YFSJ）已被观察到可缓解DDP化疗引起的化疗脑症状，但其作用机制尚不清楚。方法建立小鼠非小细胞肺癌皮下模型，并给小鼠灌胃YFSJ，探讨YFSJ减轻ddp诱导的化学脑的作用机制。通过行为学实验、脑血流量观察、网络药理学分析和组织学分析评价DDP和YFSJ对小鼠脑神经系统的影响。此外，通过体外实验验证了DDP对神经元的损伤作用和YFSJ对神经元的作用。结果syfsj减轻荷瘤小鼠全身炎症反应，恢复血脑屏障（BBB）功能，降低脑内顺铂量，减轻DDP诱导的自发性活动和脑血流微循环下降，减轻DDP引起的脑组织焦亡和铁亡。结论syfsj通过抑制肿瘤诱导的炎症来维持血脑屏障的功能稳定性，从而防止DDP进入脑组织引起的神经系统损伤引起的化学脑。

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来源期刊

Journal of Traditional and Complementary Medicine Medicine-Complementary and Alternative Medicine

CiteScore

9.30

自引率

6.70%

发文量

审稿时长

66 days

期刊介绍： eJTCM is committed to publish research providing the biological and clinical grounds for using Traditional and Complementary Medical treatments as well as studies that demonstrate the pathophysiological and molecular/biochemical bases supporting the effectiveness of such treatments. Review articles are by invitation only. eJTCM is receiving an increasing amount of submission, and we need to adopt more stringent criteria to select the articles that can be considered for peer review. Note that eJTCM is striving to increase the quality and medical relevance of the publications.