Uncommon non-fermentative gram-negative superbugs - A surge in bacteraemia patients at an apex super speciality hospital

IF 1.5 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2026-03-01 Epub Date: 2026-01-09 DOI:10.1016/j.ijmmb.2026.101046

Munaza Aman, Insha Altaf, Bashir A. Fomda, Shagufta Roohi, Anjum Mir, Sehar Tariq, Uksim Qadri

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引用次数: 0

Abstract

Background and objectives

Gram negative bacteria are most common cause of bacteraemia, with one fourth being attributed to non-fermentive Gram negative bacteria (NFGNB). Contribution of NFGNB to antimicrobial resistance burden is also high. Commonly isolated NFGNB Pseudomonas aeruginosa and Acinetobacter baumannii have been well studied however there is paucity of data of uncommon species including, Stenotrophomonas maltophilia, Burkholderia spp., Sphingomonas paucimobilis in our region. This study was thus designed to explore implication of antimicrobial resistance and associated determinants for the surge of such organisms.

Material and methods

Antimicrobial susceptibility profile of NFGNB isolates, recovered from flag positive blood culture bottles on BacT/ALERT3D system, identified by VITEK 2 compact system, over a period of one year at the department of Microbiology and risk factors associated with upsurge of common and uncommon NFGNB were also compared.

Results

A total of 133 NFGNB isolates were recovered from bacteraemia patients. Among common NFGNB, Acinetobacter baumannii (34.6 %) was commonest followed by Pseudomonas aeruginosa (15 %). While among uncommon NFGNB Acinetobacter non baumannii spp. of Acinetobacter baumannii complex were most prevalent (15 %) followed by Burkholderia cepacia complex (10.5 %) and Sphingomonas paucimobilis (8.2 %). Eighty percent of isolates were MDR and association of uncommon NFGNB surge was observed to be associated with risk factors like hospital acquired infection, recent broad spectrum antimicrobial exposure, primary bacteraemia and catheter related infection (p < 0.05).

Conclusion

Bacteraemia due to MDR NFGNB is an alarming therapeutic management challenge as empirical treatment is not effective especially for uncommon NFGNB.

Abstract Image

查看原文本刊更多论文

罕见的非发酵革兰氏阴性超级细菌-在Apex超级专科医院菌血症患者激增。

背景和目的：革兰氏阴性菌是引起菌血症的最常见原因，其中四分之一归因于非发酵革兰氏阴性菌（NFGNB）。NFGNB对抗菌素耐药性负担的贡献也很高。常见的NFGNB铜绿假单胞菌和鲍曼不动杆菌已经得到了很好的研究，但在我们地区缺乏罕见物种的数据，包括嗜麦芽窄养单胞菌、伯克霍尔德氏菌、少动鞘单胞菌。因此，本研究旨在探讨抗菌素耐药性及其相关决定因素对此类生物激增的影响。材料与方法：采用VITEK 2紧凑型系统，对我院微生物科1年多时间内从BacT/ALERT3D系统检测阳性血培养瓶中分离得到的NFGNB菌株进行药敏分析，比较常见与不常见NFGNB爆发的相关危险因素。结果：从菌血症患者中共分离到133株NFGNB。常见NFGNB中以鲍曼不动杆菌（34.6%）最为常见，其次为铜绿假单胞菌（15%）。在不常见的NFGNB不动杆菌中，鲍曼不动杆菌复群以非鲍曼不动杆菌最为常见（15%），其次是洋葱伯克氏菌复群（10.5%）和少动鞘单胞菌（8.2%）。80%的分离株为耐多药，观察到罕见的NFGNB激增与医院获得性感染、近期广谱抗菌药物暴露、原发性菌血症和导管相关感染等危险因素相关(p结论：耐多药NFGNB引起的菌血症是一个令人震惊的治疗管理挑战，因为经验治疗尤其对罕见的NFGNB无效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.