A. B. Mirkasymov, V. I. Rodionov, D. A. Pokhorukov, O. Yu. Griaznova, N. K. Ivshina, I. V. Lunyov, I. V. Zelepukin, S. M. Deyev
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引用次数: 0
Abstract
The application of porous nanomaterials in drug delivery offers a promising strategy to mitigate the adverse side effects of chemotherapy. In this study, we report the synthesis of nanosized NH2-UiO-66 (Zr) metal-organic frameworks as carriers of doxorubicin. The nanoparticles exhibited high crystallinity with an average size of 44 nm. Surface functionalization with polyethylene glycol (PEG) markedly enhanced their colloidal stability under physiological conditions. Coated NH2-UiO-66 (Zr)@PEG particles demonstrated prolonged circulation in the bloodstream and a significant reduction of nonspecific accumulation in organs with high vascularization. Importantly, these particles retained their capacity for doxorubicin loading, highlighting their potential for drug delivery.
期刊介绍：
Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.
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