Impact of hypoxia-inducible factor 1 in the oncogenic progression of Kaposi's sarcoma-associated herpes virus

IF 4.5 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI:10.1016/j.pbiomolbio.2026.01.001

Koushik Chakraborty , Monalisha Ghosh , Dristi Majumdar , Tathagata Choudhuri

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Abstract

The development of modern molecular biology helps us to identify the link between Kaposi's sarcoma-associated herpesvirus (KSHV) and multiple human malignancies by infecting B-lymphocyte or endothelial cells. Infection with KSHV plays a crucial role in stabilizing hypoxia-inducible factor-1 (HIF-1) and promoting its transcriptional activity. The association of KSHV and HIF-1 is essential for KSHV latency, reactivation, and associated disease phenotypes. In this review, we have discussed the detailed mechanisms of HIF-1 activation by KSHV infection. Based on the available evidence, we summarize the impact of HIF-1 activation on cellular metabolism, Angiogenesis, and lytic reactivation of KSHV in the proliferation and oncogenic progression of KSHV-infected B-lymphocyte or endothelial cells.

Furthermore, more studies reveal a deeper understanding of the interaction between KSHV and HIF-1. The modulatory impact of HIF-1 on the KSHV life cycle and oncogenic progression require further investigation. To advance this research, clinical trials targeting HIF-1 should commence in the near future.

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低氧诱导因子1在卡波西肉瘤相关疱疹病毒癌性进展中的影响

现代分子生物学的发展帮助我们确定卡波西肉瘤相关疱疹病毒（KSHV）通过感染b淋巴细胞或内皮细胞与多种人类恶性肿瘤之间的联系。KSHV感染在稳定缺氧诱导因子-1 （HIF-1）和促进其转录活性方面起着至关重要的作用。KSHV和HIF-1的关联对于KSHV潜伏期、再激活和相关疾病表型至关重要。在这篇综述中，我们讨论了KSHV感染激活HIF-1的详细机制。基于现有的证据，我们总结了HIF-1激活对KSHV感染的b淋巴细胞或内皮细胞增殖和癌性进展中细胞代谢、血管生成和KSHV裂解再激活的影响。此外，更多的研究揭示了KSHV与HIF-1之间相互作用的更深层次的理解。HIF-1对KSHV生命周期和癌性进展的调节作用有待进一步研究。为了推进这项研究，针对HIF-1的临床试验应该在不久的将来开始。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Biophysics & Molecular Biology 生物-生化与分子生物学

CiteScore

8.60

自引率

7.90%

发文量

审稿时长

85 days

期刊介绍： Progress in Biophysics & Molecular Biology is an international review journal and covers the ground between the physical and biological sciences since its launch in 1950. It indicates to the physicist the great variety of unsolved problems awaiting attention in biology and medicine. The biologist and biochemist will find that this journal presents new and stimulating ideas and novel approaches to studying and influencing structural and functional properties of the living organism. This journal will be of particular interest to biophysicists, biologists, biochemists, cell physiologists, systems biologists, and molecular biologists.