Urban air pollution and in vitro fertilization outcomes: A Canadian retrospective study

IF 3.4 4区医学 Q2 REPRODUCTIVE BIOLOGY

Reproductive toxicology Pub Date : 2026-03-01 Epub Date: 2026-01-07 DOI:10.1016/j.reprotox.2026.109161

Vasilia Vastis , Riki Dayan , Michael Neal , Stacy Deniz , Shilpa Amin , Megan Karnis , Karen Kteily , Catherine Friedman , Alison Holloway , Kerstyn Lutz , João Réquia Júnior Weeberb , Matthew Adams , Mehrnoosh Faghih

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引用次数: 0

Abstract

There is growing data to support an adverse relationship between air pollution and fertility. Many studies have shown that traffic-related air pollution, the most common source of urban air pollution in North America, has a negative effect on both spontaneous and IVF pregnancy outcomes. This single-center retrospective study is the first Canadian study to explore urban air pollution exposures and IVF/ICSI outcomes. It included autologous IVF/ICSI outcomes from both fresh (ET – n = 1756) and frozen embryo transfer (FET – n = 1535) cycles between 2000 and 2022. Air pollution data for fine particulate matter (PM2.5) and nitrogen dioxide (NO₂) were obtained from The Canadian Urban Environmental Health Research Consortium (CANUE). Data was analyzed using bivariate maps of long-term air pollutant exposure (PM2.5 and NO₂) and IVF/ICSI clinical outcomes by 5 km² urban areas. We found that long-term air pollution within patients’ household area ranged from 4.8 to 12.6 μg/m³ for PM2.5 and 3.2–28 ppb for NO₂. Nitrogen dioxide has demonstrated an association to some IVF/ICSI outcomes, which agrees with other international studies. No statistical associations in IVF/ICSI outcomes were found after adjusting for confounding variables. Understanding of the impact of urban air pollution on fertility and IVF/ICSI outcomes warrants further research on interventions to ameliorate negative outcomes and supports policy change(s) to improve air quality in the future.

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城市空气污染与体外受精结果：一项加拿大回顾性研究。

越来越多的数据支持空气污染与生育率之间的不利关系。许多研究表明，交通相关的空气污染是北美城市空气污染最常见的来源，对自然妊娠和体外受精妊娠结果都有负面影响。这项单中心回顾性研究是加拿大首个探讨城市空气污染暴露与IVF/ICSI结果的研究。它包括2000-2022年间新鲜（ET - n=1756）和冷冻胚胎移植（FET - n= 1535）周期的自体体外受精/ICSI结果。细颗粒物（PM2.5）和二氧化氮（NO2）的空气污染数据来自加拿大城市环境健康研究联盟（CANUE）。使用5平方公里城市区域的长期空气污染物暴露（PM2.5和NO2）和IVF/ICSI临床结果的双变量图分析数据。我们发现，患者家庭区域内的长期空气污染PM2.5为4.8至12.6μg/m3， NO2为3.2至28 ppb。二氧化氮已被证明与一些IVF/ICSI结果有关，这与其他国际研究一致。在调整混杂变量后，未发现IVF/ICSI结果的统计学关联。了解城市空气污染对生育能力和体外受精/ICSI结果的影响，可以进一步研究干预措施，以改善负面结果，并支持未来改善空气质量的政策变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive toxicology 生物-毒理学

CiteScore

6.50

自引率

3.00%

发文量

131

审稿时长

45 days

期刊介绍： Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.