The rs1800470 Polymorphism of TGF-β1 Influences the Incidence of Peri-Implantitis

IF 1.3 4区医学 Q3 GENETICS & HEREDITY

International Journal of Immunogenetics Pub Date : 2026-03-09 Epub Date: 2026-01-09 DOI:10.1111/iji.70034

Shiqi Liu, Dan Zhao, Liye Wang, Yaoyan Wang, Rongqing Hu, Fengxi Liu

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引用次数: 0

Abstract

Peri-implantitis is a pathological condition occurring in tissues around dental implants. This study aims to analyse the effect of TGF-β1 rs1800470 polymorphism on peri-implantitis. A total of 160 patients with implants without peri-implantitis and 160 patients with peri-implantitis were recruited from the clinic for this study. The genotype of TGF-β1 rs1800470 and TGF-β1 expression were detected by TaqMan-qPCR and RT-qPCR, respectively. Distributions of genotypes and allele frequencies were analysed by the chi-square test. A Hardy–Weinberg equilibrium (HWE) test was performed to detect whether the gene distribution was established. The diagnostic value of TGF-β1 for peri-implantitis was analysed by the ROC curve. TGF-β1 expression was significantly lower in peri-implantitis patients, which has diagnostic significance for peri-implantitis. TGF-β1 rs1800470 genotypic distribution conformed to the Hardy–Weinberg equilibrium test. CT and TT genotypes were significantly correlated with the development of peri-implantitis (p = 0.004, OR = 2.107, 95% CI = 1.259–3.527). CT and TT genotypes were validated as causative genotypes for peri-implantitis. Polymorphisms at the TGF-β1 rs1800470 locus have an impact on the development of peri-implantitis, and CT and TT genotypes increase the risk of developing peri-implantitis.

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TGF-β1 rs1800470多态性对种植体周围炎发病率的影响

种植体周围炎是发生在种植体周围组织的一种病理状况。本研究旨在分析TGF-β1 rs1800470多态性对种植体周围炎的影响。本研究共从临床招募了160名无种植体周围炎的种植体患者和160名种植体周围炎的患者。采用TaqMan-qPCR和RT-qPCR分别检测TGF-β1 rs1800470基因型和TGF-β1表达。采用卡方检验分析基因型分布和等位基因频率。采用Hardy-Weinberg平衡（HWE）检验检测基因分布是否成立。采用ROC曲线分析TGF-β1对种植体周围炎的诊断价值。TGF-β1在种植周炎患者中表达明显降低，对种植周炎有诊断意义。TGF-β1 rs1800470基因型分布符合Hardy-Weinberg平衡检验。CT和TT基因型与种植体周围炎的发生有显著相关性（p = 0.004, OR = 2.107, 95% CI = 1.259 ~ 3.527）。CT和TT基因型被证实为种植体周围炎的致病基因型。TGF-β1 rs1800470位点的多态性对种植体周围炎的发生有影响，CT和TT基因型增加了种植体周围炎发生的风险。

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来源期刊

International Journal of Immunogenetics 医学-免疫学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Immunogenetics (formerly European Journal of Immunogenetics) publishes original contributions on the genetic control of components of the immune system and their interactions in both humans and experimental animals. The term ''genetic'' is taken in its broadest sense to include studies at the evolutionary, molecular, chromosomal functional and population levels in both health and disease. Examples are: -studies of blood groups and other surface antigens- cell interactions and immune response- receptors, antibodies, complement components and cytokines- polymorphism- evolution of the organisation, control and function of immune system components- anthropology and disease associations- the genetics of immune-related disease: allergy, autoimmunity, immunodeficiency and other immune pathologies- All papers are seen by at least two independent referees and only papers of the highest quality are accepted.