Gender-dependent association between cardiovascular health and cognitive function in chinese older adults: a community based cohort study

IF 2.8 Q3 CLINICAL NEUROLOGY

Cerebral circulation - cognition and behavior Pub Date : 2026-01-01 Epub Date: 2025-12-16 DOI:10.1016/j.cccb.2025.100524

Bowen Wang , Yi Zeng , Virginia Byers Kraus , Xin Gao , Jixiang Ma , Xuemei Bai , Jun Na , Wei Zhe , Zhaoxue Yin

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Abstract

Objective

This study investigated the gender-dependent association of cardiovascular health, assessed by Life’s Essential 8 (LE8), with cognitive function in Chinese older adults.

Methods

Logistic regression was used to explore the relationships between LE8 scores and incident cognitive impairment as well as cognitive decline. Gender differences were examined by subgroup analyses. A generalized linear model (GLM) was used to assess the mean difference of Mini-Mental State Examination (MMSE) scores across LE8 groups.

Results

Based on logistic regression, LE8 scores were inversely correlated with prevalence of baseline cognitive impairment (OR = 0.49, 95%CI: 0.30,0.84). Higher LE8 scores were associated with reduced risk of incident cognitive impairment among participants with normal cognition at baseline (OR = 0.56, 95%CI: 0.31,0.99), although there was no significant relationship between high LE8 scores and cognitive decline. Based on subgroup analyses, there was a significant gender-based association of LE8 with incident cognitive impairment (P = 0.022), but not with cognitive decline (P = 0.424). In the female subgroup, higher LE8 scores were associated with low risk of incident cognitive impairment (OR = 0.29, 95%CI: 0.13,0.64). Based on GLM analysis, the adjusted mean MMSE score of the high LE8 group was higher than that of the low LE8 group among all participants with follow-up (adjusted mean difference = 0.44, 95%CI: 0.03,0.85); similar results were observed among those with normal cognition at baseline.

Conclusion

A higher LE8 score was significantly associated with better cognitive function in Chinese female but not male older adults.

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中国老年人心血管健康和认知功能之间的性别依赖关系：一项基于社区的队列研究

目的研究中国老年人心血管健康（LE8）与认知功能之间的性别依赖关系。方法采用logistic回归方法探讨LE8评分与事件性认知功能障碍及认知能力下降的关系。通过亚组分析检验性别差异。采用广义线性模型（GLM）评估各LE8组小学生最小精神状态检查（MMSE）得分的平均差异。结果基于logistic回归，LE8评分与基线认知障碍患病率呈负相关（OR = 0.49, 95%CI: 0.30,0.84）。在基线时认知正常的参与者中，较高的LE8评分与认知障碍发生率降低相关（OR = 0.56, 95%CI: 0.31,0.99），尽管高LE8评分与认知能力下降之间没有显著关系。基于亚组分析，LE8与认知功能障碍发生率存在显著的性别相关性（P = 0.022），但与认知功能下降无显著相关性（P = 0.424）。在女性亚组中，LE8得分越高，发生认知障碍的风险越低（OR = 0.29, 95%CI: 0.13,0.64）。经GLM分析，在所有随访的受试者中，高LE8组的调整平均MMSE评分高于低LE8组（调整平均差异= 0.44,95%CI: 0.03,0.85）；在基线认知正常的人群中也观察到类似的结果。结论LE8评分高的老年人认知功能改善与女性显著相关，而与男性无显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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