Metabolomic signaling in sarcoidosis pathogenesis

IF 5.8 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-10 DOI:10.1016/j.coi.2025.102715

Humphrey Lotana, Tristan White, Wonder Puryear Drake

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Abstract

Sarcoidosis is a multisystem inflammatory disorder characterized by noncaseating granulomas in various organs, predominantly affecting the lungs and lymphatic system. Although the etiology of sarcoidosis remains unknown, it is believed to result from an abnormal immune response triggered by environmental agents in a genetically susceptible host. The disease also has a variation in clinical outcome, with some patients spontaneously resolving their disease, while others experience disease progression. Pulmonary sarcoidosis, the most prevalent form, can progressively lead to pulmonary fibrosis, which may result in organ impairment and respiratory failure. Cellular metabolism has been implicated in numerous chronic lung diseases, making the characterization of metabolic profiles a promising approach for prognosis. A limited number of studies have examined the metabolomic profiles of sarcoidosis patients to identify key metabolites that contribute to disease progression. This review will focus on the current state of metabolomics in understanding sarcoidosis pathogenesis.

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结节病发病机制中的代谢组学信号

结节病是一种多系统炎症性疾病，以不同器官的非干酪化肉芽肿为特征，主要影响肺和淋巴系统。虽然结节病的病因尚不清楚，但它被认为是由环境因子在遗传易感宿主中引发的异常免疫反应引起的。该疾病的临床结果也有差异，一些患者的疾病会自行消退，而另一些患者则会出现疾病进展。肺结节病，最常见的形式，可逐渐导致肺纤维化，这可能导致器官损害和呼吸衰竭。细胞代谢与许多慢性肺部疾病有关，因此代谢谱的表征是一种很有前途的预后方法。有限数量的研究检查了结节病患者的代谢组学特征，以确定导致疾病进展的关键代谢物。本文将重点介绍代谢组学在了解结节病发病机制方面的研究现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.