CAR-T cells in the treatment of neurological autoimmune diseases.

IF 2.5 Q2 CLINICAL NEUROLOGY

PRACTICAL NEUROLOGY Pub Date : 2026-09-20 DOI:10.1136/pn-2025-004890

Frederick W Vonberg, Benjamin E Schroeder, Amy Edwards, Bo Sun, Ryan Y Keh, Mohammad Reza Ashraghi, Dorothy Joe, Nikos Gorgoraptis, Jeremy Rees, Nicholas W S Davies, Gerald Finnerty, Mark Willis, Maria Isabel Leite, Ralf Gold, Jeremias Motte, Aisling S Carr, Stephen Keddie

引用次数: 0

Abstract

Chimeric antigen receptor T cells (CAR-T cells) have revolutionised cancer treatment by offering personalised therapy of unprecedented efficacy to patients with relapsed B-cell malignancies and myeloma. CAR-T cells are designed selectively to target CD19 or other B-cell antigens with high affinity, leading to a potent immune response and effective killing of malignant B cells. More recently, CAR-T treatment has been shown to be safe and effective in a very limited number of patients with severe, refractory autoimmune conditions such as systemic lupus erythematosus, systemic sclerosis and myositis. This paper describes the early use and feasibility of CAR-T therapies in the treatment of refractory autoimmune neurological diseases.

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CAR-T细胞治疗神经自身免疫性疾病

嵌合抗原受体T细胞（CAR-T细胞）通过为复发的b细胞恶性肿瘤和骨髓瘤患者提供前所未有的个性化治疗，彻底改变了癌症治疗。CAR-T细胞被设计成选择性地靶向CD19或其他高亲和力的B细胞抗原，从而产生强大的免疫反应并有效杀死恶性B细胞。最近，CAR-T治疗已被证明在极少数患有严重、难治性自身免疫性疾病（如系统性红斑狼疮、系统性硬化症和肌炎）的患者中是安全有效的。本文介绍了CAR-T疗法在治疗难治性自身免疫性神经疾病中的早期应用和可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PRACTICAL NEUROLOGY Medicine-Neurology (clinical)

CiteScore

3.70

自引率

3.60%

发文量

113

期刊介绍： The essential point of Practical Neurology is that it is practical in the sense of being useful for everyone who sees neurological patients and who wants to keep up to date, and safe, in managing them. In other words this is a journal for jobbing neurologists - which most of us are for at least part of our time - who plough through the tension headaches and funny turns week in and week out. Primary research literature potentially relevant to routine clinical practice is far too much for any neurologist to read, let alone understand, critically appraise and assimilate. Therefore, if research is to influence clinical practice appropriately and quickly it has to be digested and provided to neurologists in an informative and convenient way.