Investigation of serum orexin-A levels in women with polycystic ovary syndrome.

IF 1.9 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrine Research Pub Date : 2026-02-01 Epub Date: 2026-01-04 DOI:10.1080/07435800.2025.2611822

Yağmur Ağlıç, İbrahim Kale

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引用次数: 0

Abstract

Objective: Orexin-A (OXA) is a hypothalamic neuropeptide implicated in glucose regulation and insulin sensitivity. Given the central role of insulin resistance in polycystic ovary syndrome (PCOS), this study evaluated serum OXA levels in women with PCOS.

Methods: This cross-sectional case-control study included 88 women with PCOS and 88 age- and body mass index-matched controls. Serum OXA levels were quantified using a commercial ELISA kit.

Results: Serum OXA levels were significantly lower in women with PCOS than in controls (321.53 ng/L vs. 385.06 ng/L, p = 0.012). A significant negative correlation was observed between the modified Ferriman-Gallwey score and serum OXA level. In the ROC analysis, a serum OXA level of 369.55 ng/L yielded a sensitivity of 55.7% and a specificity of 55.7% (AUC: 0.610) for detecting PCOS.

Conclusions: Serum OXA concentrations were reduced in women with PCOS. Whether this reduction contributes to PCOS pathogenesis or reflects a secondary alteration remains uncertain.

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多囊卵巢综合征患者血清促食欲素a水平的研究。

目的：食欲素- a （OXA）是一种参与葡萄糖调节和胰岛素敏感性的下丘脑神经肽。鉴于胰岛素抵抗在多囊卵巢综合征（PCOS）中的核心作用，本研究评估了多囊卵巢综合征女性血清OXA水平。方法：本横断面病例对照研究包括88名多囊卵巢综合征女性和88名年龄和体重指数匹配的对照组。使用商用ELISA试剂盒定量测定血清OXA水平。结果：多囊卵巢综合征患者血清OXA水平明显低于对照组（321.53 ng/L vs. 385.06 ng/L, p = 0.012）。修正后的Ferriman-Gallwey评分与血清OXA水平呈显著负相关。在ROC分析中，血清OXA水平为369.55 ng/L，检测PCOS的敏感性为55.7%，特异性为55.7% （AUC: 0.610）。结论：多囊卵巢综合征患者血清OXA浓度降低。这种减少是否有助于多囊卵巢综合征发病机制或反映继发性改变仍不确定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.