{"title":"Cellular and Molecular Aspects of Chronic Rejection.","authors":"Zhongcheng Mei, Alexander Sasha Krupnick","doi":"10.1007/978-3-032-07686-1_1","DOIUrl":null,"url":null,"abstract":"<p><p>Chronic rejection is a principal cause of long-term graft failure in solid organ transplantation. Characterized by progressive fibrotic remodeling, chronic rejection results from complex interactions among alloimmune responses, persistent inflammation, and dysregulated tissue repair mechanisms. This chapter provides a comprehensive overview of the cellular and molecular mechanisms underlying chronic rejection, with a focus on the roles of innate immune cells, T and B lymphocytes, profibrotic cytokines, signaling pathways, and extracellular matrix remodeling. A detailed mechanistic understanding of these pathways is critical for the identification of novel biomarkers and the development of targeted therapeutic strategies to prevent or ameliorate chronic rejection, thereby improving long-term graft survival.</p>","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"77 ","pages":"3-23"},"PeriodicalIF":0.0000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Results and Problems in Cell Differentiation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-032-07686-1_1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Chronic rejection is a principal cause of long-term graft failure in solid organ transplantation. Characterized by progressive fibrotic remodeling, chronic rejection results from complex interactions among alloimmune responses, persistent inflammation, and dysregulated tissue repair mechanisms. This chapter provides a comprehensive overview of the cellular and molecular mechanisms underlying chronic rejection, with a focus on the roles of innate immune cells, T and B lymphocytes, profibrotic cytokines, signaling pathways, and extracellular matrix remodeling. A detailed mechanistic understanding of these pathways is critical for the identification of novel biomarkers and the development of targeted therapeutic strategies to prevent or ameliorate chronic rejection, thereby improving long-term graft survival.
期刊介绍：
Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.
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