The traffic controller: GARLH4 dictates neuroligin synapse-type preference.

IF 6.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2026-02-02 Epub Date: 2026-01-02 DOI:10.1083/jcb.202512185

Eunjoon Kim

引用次数: 0

Abstract

Neuroligin isoforms are commonly thought to intrinsically specify synapse identity. In this issue, Yamasaki et al. (https://doi.org/10.1083/jcb.202507190) show that the auxiliary protein GARLH4 (LHFPL4) instead dictates neuroligin preference via competitive hierarchy, enabling dynamic reassignment between excitatory and inhibitory postsynaptic domains.

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交通控制：GARLH4决定神经素突触型偏好。

神经胶质素异构体通常被认为内在地指定突触身份。在这期杂志中，Yamasaki等人（https://doi.org/10.1083/jcb.202507190）表明，辅助蛋白GARLH4 （LHFPL4）通过竞争层次决定了神经素的偏好，从而实现了兴奋性和抑制性突触后结构域之间的动态重新分配。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.