Brain biochemical metabolism using proton magnetic resonance spectroscopy in adolescents bipolar depression with verbal auditory hallucinations

IF 2.4 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging Pub Date : 2026-04-01 Epub Date: 2025-12-31 DOI:10.1016/j.pscychresns.2025.112135

Qinnaer Bolatijiang , Shaohong Zou , Chengji Wang , Jianliang Zhang , Zhiyuan Chen , Longyuan Zhang

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引用次数: 0

Abstract

Objective

This study utilizes proton magnetic resonance spectroscopy (¹H-MRS) imaging to analyze neuro-metabolic alterations in the ventromedial prefrontal cortex (vmPFC) of adolescents with bipolar depression (BD-Dep) and verbal auditory hallucinations (AVHs).

Methods

A retrospective analysis was conducted on 47 untreated adolescent BD-Dep patients within 30 days, between January 2024 and August 2025. Comprehensive clinical data were collected for all patients, including gender, age, age of onset, years of education, and the presence of suicidal or self-harming behaviors. Patients were divided into two groups: an AVH group (P3 score >3, n = 24) and a non-hallucination group (P3 score ≤3, n = 23), based on PANSS P3 scores and the presence of AVHs. Both groups underwent ¹H-MRS scanning of the vmPFC to compare the ratios of N-acetyl aspartate/creatine (NAA/Cr), choline/creatine (Cho/Cr), myo-inositol/creatine (mI/Cr), glutamate/creatine (Glu/Cr), and NAA/Cho.

Results

The comparison of Cho/Cr ratios between the two groups—0.685 (0.653, 0.748) versus 0.600 (0.530, 0.650)—revealed a statistically significant difference (Z = 3.346, P = 0.001, <0.05). No statistically significant differences were found in the NAA/Cr, mI/Cr, and Glu/Cr ratios between the two groups.

Conclusion

Adolescent BD-Dep patients with AVHs exhibit elevated Cho/Cr ratios. These biochemical metabolic changes in the vmPFC may be associated with the occurrence of AVHs in these patients.

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用质子磁共振波谱分析青少年双相抑郁伴言语幻听的脑生化代谢

目的利用质子磁共振波谱（1H-MRS）成像技术分析青少年双相抑郁（BD-Dep）和言语幻听（AVHs）患者腹内侧前额叶皮层（vmPFC）的神经代谢变化。方法回顾性分析2024年1月至2025年8月期间47例未经治疗的青春期BD-Dep患者30天内的临床资料。收集所有患者的综合临床资料，包括性别、年龄、发病年龄、受教育年限、是否有自杀或自残行为。根据PANSS P3评分及AVH是否存在将患者分为AVH组（P3评分≤3，n = 24）和无幻觉组（P3评分≤3，n = 23）。两组均对vmPFC进行1H-MRS扫描，比较n -乙酰天冬氨酸/肌酸（NAA/Cr）、胆碱/肌酸（Cho/Cr）、肌醇/肌酸（mI/Cr）、谷氨酸/肌酸（Glu/Cr）和NAA/Cho的比值。结果两组患者Cho/Cr比值分别为0.685（0.653,0.748）和0.600(0.530,0.650)，差异有统计学意义（Z = 3.346, P = 0.001, <0.05）。两组间NAA/Cr、mI/Cr、Glu/Cr比值无统计学差异。结论青少年bd - deep AVHs患者Cho/Cr比值升高。这些vmPFC的生化代谢变化可能与这些患者中AVHs的发生有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.