Triglyceride-glucose index and risks of suicide mortality in young adults: a nationwide population-based study.

IF 3.7 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Epidemiology and Community Health Pub Date : 2026-05-08 DOI:10.1136/jech-2025-224962

Yu Ho Lee, Kyungdo Han, Hye Eun Yoon, Sungjin Chung, Hyeon Seok Hwang

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引用次数: 0

Abstract

Background: Suicide is a leading cause of death among young adults in South Korea. We investigated the association between triglyceride-glucose (TyG) index and suicide mortality in young adults.

Methods: This nationwide study analysed data from 6 667 138 individuals aged 20-39 using the National Health Insurance Database. Participants were grouped into TyG index quartiles. The primary outcome was suicide mortality.

Results: During a median follow-up duration of 10.7 years, 41 004 (0.6%) suicidal deaths occurred. The cumulative event rates for suicide mortality were highest among participants in TyG index quartile 4. Multivariable Cox analysis showed significant increases in the risks of suicide mortality in participants with TyG index quartile 4 compared with those in the low quartiles (adjusted HR 1.17, 95% CI 1.11 to 1.23, vs quartile 1; adjusted HR 1.15, 95% CI 1.10 to 1.20, vs quartile 1-3). The association between the TyG index and the risks of suicide mortality was positive and quasi-linear. Subgroup analysis showed a consistent trend of increasing HRs for suicide mortality with higher TyG index quartiles, with significant interactions between TyG index, sex and depression.

Conclusion: TyG index can be useful in identifying young individuals at an increased risk of suicide mortality.

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甘油三酯-葡萄糖指数与年轻人自杀死亡率的风险：一项全国性的基于人群的研究

背景：自杀是韩国年轻人死亡的主要原因。我们调查了甘油三酯-葡萄糖（TyG）指数与年轻人自杀死亡率之间的关系。方法：这项全国性研究使用国家健康保险数据库分析了6 667 138名年龄在20-39岁之间的人的数据。参与者被分为TyG指数四分位数。主要结局为自杀死亡率。结果：在10.7年的中位随访期间，发生了410004例（0.6%）自杀死亡。自杀死亡率的累积事件率在TyG指数四分位数4的参与者中最高。多变量Cox分析显示，TyG指数四分位数4的参与者的自杀死亡率风险显著高于低四分位数的参与者（调整后的风险比1.17,95% CI 1.11至1.23，与四分位数1相比；调整后的风险比1.15,95% CI 1.10至1.20，与四分位数1-3相比）。TyG指数与自杀死亡风险呈拟线性正相关。亚组分析显示，TyG指数四分位数越高，自杀死亡率呈上升趋势，且TyG指数、性别和抑郁之间存在显著交互作用。结论：TyG指数可用于识别自杀死亡风险增加的年轻人。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Epidemiology and Community Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

11.10

自引率

0.00%

发文量

100

审稿时长

3-6 weeks

期刊介绍： The Journal of Epidemiology and Community Health is a leading international journal devoted to publication of original research and reviews covering applied, methodological and theoretical issues with emphasis on studies using multidisciplinary or integrative approaches. The journal aims to improve epidemiological knowledge and ultimately health worldwide.