Akkermansia muciniphila: A double-edged sword in life-stage-specific nutritional modulation of Parkinson’s disease via the gut-brain axis

IF 8.5 1区生物学 Q1 MICROBIOLOGY

Microbiological research Pub Date : 2026-04-01 Epub Date: 2025-12-29 DOI:10.1016/j.micres.2025.128436

Nan Chen , Dejiang Pang , Huifang Shang

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引用次数: 0

Abstract

The gut mucin specialist Akkermansia muciniphila (A. muciniphila) exhibits a paradoxical duality in PD, showing both positive and negative correlations with motor and non-motor symptoms across distinct PD subtypes. This enigmatic role is further complicated by its dynamic lifespan trajectory: colonizing early life, peaking in adulthood, declining with aging, yet resurging in longevity cohorts. This review synthesizes evidence on A. muciniphila's structural components, its divergent associations with PD phenotypes, and the dietary and host factors shaping its abundance from gestation to senescence. We propose a lifespan-targeted intervention model that strategically modulates A. muciniphila, which could concurrently mitigate PD progression and promote healthy aging. We suggest suppressing its neurotoxic pathways in susceptible individuals while enhancing its beneficial functions in the aging process. Reconciling this microbial Janus face may pave the way for novel microbiome-based precision therapeutics against neurodegeneration.

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嗜muciniphila：通过肠-脑轴对帕金森病进行生命阶段特异性营养调节的双刃剑。

肠道粘蛋白专家嗜粘杆菌（a.m uiniphila）在PD中表现出矛盾的二元性，在不同的PD亚型中显示出与运动和非运动症状的正相关和负相关。这种神秘的作用因其动态的生命轨迹而变得更加复杂：在生命早期占据主导地位，在成年期达到顶峰，随着年龄的增长而下降，但在长寿人群中又重新出现。本文综述了嗜粘液芽孢杆菌的结构成分，其与PD表型的不同关联，以及饮食和宿主因素对其从妊娠到衰老丰度的影响。我们提出了一种以寿命为目标的干预模型，该模型可以战略性地调节嗜粘液芽胞杆菌，从而同时缓解PD的进展并促进健康衰老。我们建议抑制易感个体的神经毒性通路，同时增强其在衰老过程中的有益功能。调和这种微生物双面面可能为新的基于微生物组的精确治疗神经变性铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiological research 生物-微生物学

CiteScore

10.90

自引率

6.00%

发文量

249

审稿时长

29 days

期刊介绍： Microbiological Research is devoted to publishing reports on prokaryotic and eukaryotic microorganisms such as yeasts, fungi, bacteria, archaea, and protozoa. Research on interactions between pathogenic microorganisms and their environment or hosts are also covered.