Efficacy of Platelet-Rich Plasma and Polyvinyl Alcohol Wound Dressing in Open Wound Healing: First Results from an Experimental Rat Model.

IF 2.5 4区医学 Q2 SURGERY

European Surgical Research Pub Date : 2026-01-01 Epub Date: 2025-12-31 DOI:10.1159/000550016

Umit Akin Dere, Fatma Altintas, Baris Albuz, Nazli Çil, Pelin Kuzucu, Esin Avci, Hande Senol, Ahmet Koluman, Mehmet Erdal Coskun

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引用次数: 0

Abstract

Introduction: Wound healing is a complex biological process involving hemostasis, inflammation, proliferation, and tissue remodeling. Despite promising results with platelet-rich plasma (PRP) and synthetic scaffolds used separately, their combined in vivo effects remain insufficiently investigated. This experimental study presents the first results on a composite wound dressing integrating PRP, rich in growth factors, with electrospun polyvinyl alcohol (PVA) nanofibers, a biocompatible and stable polymer.

Methods: Full-thickness skin defects (1 × 1 cm2) were created in 21 adult female Sprague-Dawley rats and divided into three groups: control, PVA, and PRP/PVA. Wound healing was assessed histologically and biochemically on days 7 and 14, including fibroblast growth factor-2 (FGF-2) measurement.

Results: The PRP/PVA group showed enhanced epithelialization and angiogenesis compared to other groups (p < 0.05), along with higher FGF-2 levels.

Conclusion: The relatively small sample size, absence of a PRP-only group, and short observation period limit the generalizability of these findings. Within these constraints, the results indicate a potential synergistic role of PRP and PVA scaffolds in promoting wound repair, supporting further studies with larger cohorts and standardized PRP preparation before clinical translation.

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富血小板血浆和聚乙烯醇（PRP/PVA）敷料在开放性伤口愈合中的作用：实验大鼠模型的初步结果

伤口愈合是一个复杂的生物学过程，涉及止血、炎症、增殖和组织重塑。尽管富血小板血浆（PRP）和合成支架分别使用的结果很有希望，但它们在体内的联合效应仍然没有得到充分的研究。本实验研究首次提出了一种将富含生长因子的PRP与生物相容性和稳定性聚合物聚乙烯醇（PVA）纳米纤维结合在一起的复合伤口敷料。21只成年雌性Sprague-Dawley大鼠形成全层皮肤缺损（1×1 cm²），分为对照组、PVA组和PRP/PVA组。在第7天和第14天对伤口愈合进行组织学和生化评估，包括测量成纤维细胞生长因子-2 （FGF-2）。与其他组相比，PRP/PVA组的上皮化和血管生成增强(p

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来源期刊

European Surgical Research 医学-外科

CiteScore

2.30

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： ''European Surgical Research'' features original clinical and experimental papers, condensed reviews of new knowledge relevant to surgical research, and short technical notes serving the information needs of investigators in various fields of operative medicine. Coverage includes surgery, surgical pathophysiology, drug usage, and new surgical techniques. Special consideration is given to information on the use of animal models, physiological and biological methods as well as biophysical measuring and recording systems. The journal is of particular value for workers interested in pathophysiologic concepts, new techniques and in how these can be introduced into clinical work or applied when critical decisions are made concerning the use of new procedures or drugs.