Synthesis of 3-benzoylisoxazolines by copper(Ⅰ) bromide-catalyzed 1,3-dipolar cycloaddition of nitroketones with dipolarophiles

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2026-04-01 Epub Date: 2025-12-11 DOI:10.1016/j.tet.2025.135088

Xiaoyu Liao , Zhiyun Zhao , Jiyi Lv , Xiling Deng , Xinrun Zhao , Yangzi Chen , Wei Zhang , Pinghua Sun , Xinhui Pan

引用次数: 0

Abstract

An efficient copper(Ⅰ) bromide catalyzed 1,3-dipolar cycloaddition reaction of different α-nitroketones with dipolarophiles has been investigated. These reactions afford the corresponding 3-benzoylisoxazolines in moderate to high yields (up to 99.9 %) under mild conditions. This method provides an economical and simple route to construction of isoxazole or isoxazoline ring.

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溴化铜（Ⅰ）催化硝基酮与亲偶极试剂1,3-偶极环加成合成3-苯甲酰异恶唑啉

研究了溴化铜（Ⅰ）催化不同α-硝基酮与亲偶极试剂的1,3-偶极环加成反应。这些反应在温和的条件下产生相应的3-苯甲酰异恶唑啉，产率中高（可达99.9%）。该方法为构建异恶唑或异恶唑啉环提供了一条经济、简便的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.