Optimization of memory neurofeedback system utilizing intracranial electroencephalogram of the hippocampus

IF 3.4 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2025-12-22 DOI:10.1016/j.clinph.2025.2111490

Ako Matsuhashi , Seijiro Shimada , Naoto Kunii , Takeshi Matsuo , Anna Takeda , Toshiya Aono , Shigeta Fujitani , Keisuke Nagata , Makoto Sato , Yohei Ishishita , Kenji Ibayashi , Keisuke Ohtani , Yoshiyuki Onuki , Kensuke Kawai , Nobuhito Saito

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引用次数: 0

Abstract

Objective

Patients with temporal lobe epilepsy (TLE) suffer from epileptic seizures and memory decline. While focal resection eliminates seizures in 60–70% of patients, surgery carries the risk of further compromising memory. We hypothesized that hippocampal neurofeedback (NF) will induce targeted brain activity associated with memory function.

Methods

Patients with intracranial electrodes implanted in bilateral hippocampi performed a memory NF task, developed specifically for this project. The NF task involved real-time analysis of hippocampal activity using the electrode in the less-affected hippocampus while conducting a memory task. Changes in theta activity and task performance were assessed.

Results

The NF task was conducted in seven TLE patients. In five patients, theta activity increased significantly in the targeted hippocampus (Mann-Kendall test; p < 0.05). Mixed linear model analysis across all sessions revealed a significant increase in theta activity in the targeted hippocampus (p = 0.0032), with no significant change contralaterally (p = 0.19). Three additional TLE patients underwent random NF to assess if theta activity was induced merely by the encoding process, but none of them showed significant changes in theta activity.

Conclusion

Memory NF task effectively induced targeted hippocampal activity in TLE patients.

Significance

Hippocampal NF may enhance memory function in TLE patients prior to focal resection.

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利用颅内海马脑电图优化记忆神经反馈系统

目的颞叶癫痫（TLE）患者以癫痫发作和记忆减退为主。虽然局灶性切除可消除60-70%患者的癫痫发作，但手术有进一步损害记忆的风险。我们假设海马神经反馈（NF）将诱导与记忆功能相关的目标脑活动。方法在双侧海马体植入脑内电极的患者执行专门为该项目开发的记忆NF任务。NF任务包括在执行记忆任务时，利用电极在受影响较小的海马体上实时分析海马体活动。评估θ波活动和任务表现的变化。结果7例TLE患者均完成了NF任务。在5例患者中，靶海马区θ活动显著增加（Mann-Kendall检验；p < 0.05）。所有疗程的混合线性模型分析显示，靶海马的θ活动显著增加（p = 0.0032），而对侧无显著变化（p = 0.19）。另外三名TLE患者接受了随机NF试验，以评估θ活动是否仅仅由编码过程引起，但没有人显示出θ活动的显著变化。结论记忆NF任务可有效诱导TLE患者海马靶向活动。意义海马NF可增强TLE患者局灶性切除前的记忆功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.