The role of pertussis toxin in clinical manifestations of pertussis

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2026-03-01 Epub Date: 2025-12-23 DOI:10.1016/j.toxicon.2025.108972

Wenjuan Zhao , Meng Dang , Shuyue Tang , Min Hao , Zengguo Wang

引用次数: 0

Abstract

Pertussis is an acute respiratory infectious disease caused by Bordetella pertussis (B. pertussis). In recent years, the resurgence of pertussis has once again drawn widespread attention from the academic community and society at large. The pathogenicity of B. pertussis depends on multiple virulence factors, among which pertussis toxin (PT) is widely recognized as its core virulence factor. PT, with its unique AB₅ structure and ADP-ribosylase activity, broadly disrupts host cell signal transduction. However, the specific role of PT in the complex pathogenic mechanisms of pertussis remains incompletely understood. This review systematically summarizes the molecular structural characteristics and mechanisms of action of PT, with a particular focus on its potential role in the typical and unique clinical manifestations and severe complications of pertussis.

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百日咳毒素在百日咳临床表现中的作用。

百日咳是由百日咳杆菌（B. Pertussis）引起的急性呼吸道传染病。近年来，百日咳的死灰复燃再次引起学术界和社会的广泛关注。百日咳的致病性取决于多种毒力因子，其中百日咳毒素（pertussis toxin， PT）被广泛认为是其核心毒力因子。PT具有独特的AB5结构和adp核糖基酶活性，广泛地干扰宿主细胞信号转导。然而，PT在百日咳复杂致病机制中的具体作用仍不完全清楚。本文系统综述了PT的分子结构特征和作用机制，重点介绍了PT在百日咳典型独特临床表现和严重并发症中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

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