Single-arm longitudinal study to assess changes in insula functional connectivity following a mobile-based lifestyle intervention in adults with metabolic abnormalities

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2026-02-01 Epub Date: 2025-12-14 DOI:10.1016/j.jpsychores.2025.112498

Deokjong Lee , Kyung Mee Park , Jihye Kim , Sin Young Ko , Byeonghee Lee , Chae Jung Park , Kyoung Min Kim , Jin Young Park

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引用次数: 0

Abstract

Backgrounds

Mobile-based lifestyle intervention has been widely used to improve behavior for obesity and overweight. This study targeting adults with metabolic abnormalities aims to identify neural correlates related to weight loss due to mobile-based lifestyle intervention.

Methods

We conducted 8 weeks of mobile-based lifestyle intervention for 37 adults with metabolic abnormalities, including overweight. Participants underwent physical measurements, blood tests, psychometric questionnaires, and resting-state functional magnetic resonance imaging (fMRI) scans before and after the mobile-based intervention. For the resting-state fMRI, brain regions that showed changes in functional connectivity (FC) before and after mobile-based intervention were explored. Seed-based FC analysis was performed focusing on the subregions of the insular cortex.

Results

Participants significantly reduced body mass index (BMI) after mobile-based intervention. The degree of BMI reduction was significantly correlated with compliance with the intervention. In resting fMRI, FC of the posterior insula with the bilateral inferior parietal lobule and the left ventrolateral prefrontal cortex were enhanced after mobile-based intervention. The increase in FC between the posterior insula and the inferior posterior lobule showed a significant correlation with the decrease in binge eating scale scores.

Conclusion

The mobile-based lifestyle intervention significantly reduced weight and alleviated binge eating in adults with metabolic abnormalities. FC enhancement between the posterior insula and the frontoparietal regions was also observed after mobile-based lifestyle intervention. The relationship between these FC changes and strengthening weight control through mobile-based lifestyle intervention should be investigated through future research.

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单臂纵向研究评估代谢异常成人在移动生活方式干预后脑岛功能连通性的变化。

背景：基于手机的生活方式干预已被广泛用于改善肥胖和超重的行为。这项针对成人代谢异常的研究旨在确定基于移动的生活方式干预与体重减轻相关的神经相关性。方法：我们对37名代谢异常（包括超重）的成年人进行了8周的基于移动的生活方式干预。参与者在移动干预前后接受了身体测量、血液测试、心理测量问卷和静息状态功能磁共振成像（fMRI）扫描。对于静息状态fMRI，研究人员探索了在基于移动的干预前后显示功能连接（FC）变化的大脑区域。基于种子的FC分析集中在岛叶皮层的亚区。结果：参与者在移动干预后显著降低了身体质量指数（BMI）。BMI降低程度与干预依从性显著相关。静息fMRI显示，运动干预后，脑岛后部与双侧下顶叶和左腹外侧前额叶皮层的FC增强。后岛叶和下后小叶之间FC的增加与暴食量表得分的下降有显著相关。结论：以移动为基础的生活方式干预可显著减轻代谢异常成人的体重和暴饮暴食。在以移动为基础的生活方式干预后，也观察到脑岛后部和额顶叶区域之间的FC增强。这些FC变化与通过基于移动的生活方式干预加强体重控制之间的关系应该通过未来的研究来调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.