Younger midlife females with bilateral salpingo-oophorectomy: respiratory disturbances during sleep.

IF 3.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2026-04-01 Epub Date: 2025-12-22 DOI:10.1080/13697137.2025.2595987

Laura Gravelsins, Nicole J Gervais, Alana Brown, Shreeyaa Ramana, Sophia Zhao, Gina Nicoll, Marcus Q Bernardini, Michelle Jacobson, Gillian Einstein

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引用次数: 0

Abstract

Objective: There are many menopauses; bilateral oophorectomy is associated with the worst cognitive outcomes. Compared to females with intact ovaries, females with bilateral oophorectomy experience early, abrupt ovarian hormone loss and are at increased risk for later-life Alzheimer's disease. They also have double the odds of developing later-life sleep disordered breathing (SDB) - a modifiable Alzheimer's risk factor. With respect to bilateral oophorectomy, it is unknown when respiratory disturbances occur or whether estradiol therapy (ET) ameliorates them. Also unknown is whether SDB influences cognition in this group.

Method: Females with risk-reducing bilateral salpingo-oophorectomy (BSO) taking ET (BSO+ET, n = 19) or not (BSO, n = 16) and premenopausal age-matched controls (AMC, n = 17) were assessed for SDB markers using take-home polysomnography and for working memory performance.

Results: The BSO group showed signs of respiratory disturbance compared to the AMC group. Memory performance was uncorrelated with respiratory metrics. While the BSO+ET group showed an intermediate sleep phenotype, estrone glucuronide levels correlated with improved respiratory metrics.

Conclusion: The results suggest that respiratory disturbances manifest as early as 5 years post-BSO in younger females; ET offers some amelioration. The close relationship between sleep disruption and Alzheimer's risk emphasizes the importance of SDB screening post-BSO for early intervention.

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双侧输卵管卵巢切除术的年轻中年女性：睡眠时呼吸障碍。

目的：绝经患者较多；双侧卵巢切除术与最差的认知结果相关。与卵巢完整的女性相比，双侧卵巢切除的女性经历了早期、突然的卵巢激素丧失，晚年患阿尔茨海默病的风险增加。他们患上睡眠呼吸障碍（SDB）的几率也会增加一倍——这是一种可改变的阿尔茨海默氏症风险因素。对于双侧卵巢切除术，尚不清楚何时发生呼吸障碍或雌二醇治疗（ET）是否能改善它们。同样未知的是SDB是否会影响这一群体的认知。方法：采用带回家多导睡眠描记仪评估双侧输卵管卵巢切除术（BSO）降低风险的女性（BSO+ET, n = 19）或不服用ET （BSO, n = 16）和绝经前年龄匹配对照组（AMC, n = 17）的SDB标志物和工作记忆表现。结果：与AMC组相比，BSO组出现呼吸障碍症状。记忆表现与呼吸指标无关。虽然BSO+ET组表现出中间睡眠表型，但雌酮葡萄糖醛酸水平与呼吸指标的改善相关。结论：年轻女性早在bso后5年就出现呼吸障碍；ET提供了一些改进。睡眠障碍与阿尔茨海默病风险之间的密切关系强调了bso后SDB筛查对早期干预的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.