A conceptual model of oxygen-ozone therapy as a modulator of aging via the HMGB1 pathway.

IF 4.1 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2025-12-23 DOI:10.1007/s10522-025-10375-z

Salvatore Chirumbolo, Luigi Valdenassi, Dario Bertossi, Fortunato Loprete, Umberto Tirelli, Marianno Franzini

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引用次数: 0

Abstract

Objectives: To evaluate whether oxygen-ozone therapy (OOT) can modulate aging by inducing adaptive chaos in the HMGB1-Nrf2 redox-inflammatory pathway.

Methods: A computational systems biology model simulated feedback loops among ROS, Nrf2, HMGB1, and NF-κB under varying ozone doses and cellular contexts (protective vs. autophagy-deficient).

Results: Intermediate ozone doses in the model triggered controlled chaos. The model suggests a potential 'chaotic window' (30-40 μg/mL ozone) that may promote redox resilience in autophagy-deficient cells.

Conclusion: OOT may potentially contribute to healthy aging by modulating redox adaptability. Its theoretical effectiveness is dose-dependent, with maximal benefit in aged or dysfunctional systems requiring reactivation of flexible stress responses. However, while the model offers insights into possible dynamic behaviours of the redox-inflammatory axis under ozone exposure, it is not yet calibrated to biological data and cannot predict real-world outcomes without further experimental support.

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氧-臭氧疗法通过HMGB1通路作为衰老调节剂的概念模型。

目的：探讨氧臭氧疗法（OOT）能否通过诱导HMGB1-Nrf2氧化还原-炎症通路的适应性混乱来调节衰老。方法：计算系统生物学模型模拟了不同臭氧剂量和细胞环境（保护性与自噬缺陷）下ROS、Nrf2、HMGB1和NF-κB之间的反馈回路。结果：模型中臭氧的中间剂量引发了可控混沌。该模型表明，潜在的“混沌窗口”（30-40 μg/mL臭氧）可能促进自噬缺陷细胞的氧化还原弹性。结论：OOT可能通过调节氧化还原适应性而促进健康衰老。它的理论有效性是剂量依赖性的，在需要重新激活灵活应激反应的老年或功能失调系统中具有最大的益处。然而，尽管该模型提供了臭氧暴露下氧化还原-炎症轴可能的动态行为的见解，但它尚未校准为生物学数据，并且在没有进一步实验支持的情况下无法预测现实世界的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.