Starting Age for Screening Metabolic Dysfunction-Associated Steatotic Liver Disease in Children Using Controlled Attenuation Parameter on Transient Elastography

IF 2.5 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2025-12-22 DOI:10.1111/ijpo.70080

Li-Wen Lee, Jrhau Lung, Ju-Bei Yen, Chao-Yu Chen, Yu-San Liao

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引用次数: 0

Abstract

Background

Rising sedentary behaviour and consumption of sugar-sweetened beverages and ultra-processed foods have increased the risk and earlier onset of obesity in children.

Objectives

To define controlled attenuation parameter (CAP) cut-off values in healthy children, assess the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in children with overweight and obesity, and establish an appropriate starting age for MASLD screening in our population.

Methods

Healthy primary school children were recruited. Hepatic steatosis was assessed using CAP, and body composition data were collected during two periods: August 2020–March 2021 and February 2023–May 2024.

Results

Of 1653 participants (mean age 9.5 ± 1.7 years), 976 children with normal weight were used to establish reference intervals. Hepatic steatosis was defined as a CAP above 247 dB/m (97.5th percentile). The prevalences of MASLD in children with overweight and obesity were 0% and 16%, respectively, in school grade 1, which increased to 19% and 75% in school grade 6 (p < 0.001).

Conclusions

Screening for hepatic steatosis associated with obesity should begin as early as school grade 1, while screening for children with overweight may be more appropriate by school grade 6. These findings emphasise the need for age- and weight-specific screening strategies for children with overweight and obesity.

Abstract Image

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用瞬时弹性成像控制衰减参数筛选儿童代谢功能障碍相关脂肪变性肝病的起始年龄

背景：越来越多的久坐行为和含糖饮料和超加工食品的消费增加了儿童肥胖的风险和早期发病。目的：确定健康儿童的控制衰减参数（CAP）临界值，评估超重和肥胖儿童代谢功能障碍相关脂肪变性肝病（MASLD）的患病率，并在我国人群中建立MASLD筛查的合适起始年龄。方法：招募健康小学生。使用CAP评估肝脂肪变性，并在2020年8月至2021年3月和2023年2月至2024年5月两个时期收集体成分数据。结果：1653名参与者（平均年龄9.5±1.7岁）中，976名体重正常的儿童被用于建立参考区间。肝脂肪变性定义为CAP高于247 dB/m（97.5%）。超重和肥胖儿童的MASLD患病率在一年级分别为0%和16%，在六年级分别增加到19%和75% (p结论：与肥胖相关的肝脂肪变性筛查应早在一年级开始，而超重儿童的筛查可能更适合在六年级进行。这些发现强调了对超重和肥胖儿童进行年龄和体重特异性筛查策略的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.