Seleem Badawy, Varshiny Gopinath, Ana M Diaz Espinosa, Kasinan Suthiwanich, Ethan C Kelmser, Victoria Duke, Veda Kamaraju, Karina Nakayama, Manoj Manna, Julianne J-Y Liu, Sara S Nunes, Keyue Shen, Ngan F Huang
{"title":"Tissue regenerative medicine: Clinical advances, challenges, and opportunities.","authors":"Seleem Badawy, Varshiny Gopinath, Ana M Diaz Espinosa, Kasinan Suthiwanich, Ethan C Kelmser, Victoria Duke, Veda Kamaraju, Karina Nakayama, Manoj Manna, Julianne J-Y Liu, Sara S Nunes, Keyue Shen, Ngan F Huang","doi":"10.1063/5.0296897","DOIUrl":null,"url":null,"abstract":"<p><p>Regenerative medicine is transforming how we restore tissue function, leveraging advances in cell and molecular biology, biomaterials, and engineered microenvironments. While there have been notable advances and rapid progress over the past few decades, ongoing challenges persist in the technical development and effective translation of these advancements to clinical care. This perspective highlights clinically promising examples and critically assesses present challenges in translating tissue regenerative medicine therapies from the bench to the clinic. We further examine the evolving landscape of regenerative medicine by describing strategies to optimize the cellular microenvironment, the impact of patient demographics, and the use of artificial intelligence to shape the future of this field.</p>","PeriodicalId":46288,"journal":{"name":"APL Bioengineering","volume":"9 4","pages":"040902"},"PeriodicalIF":4.9000,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12716889/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"APL Bioengineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1063/5.0296897","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/12/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Regenerative medicine is transforming how we restore tissue function, leveraging advances in cell and molecular biology, biomaterials, and engineered microenvironments. While there have been notable advances and rapid progress over the past few decades, ongoing challenges persist in the technical development and effective translation of these advancements to clinical care. This perspective highlights clinically promising examples and critically assesses present challenges in translating tissue regenerative medicine therapies from the bench to the clinic. We further examine the evolving landscape of regenerative medicine by describing strategies to optimize the cellular microenvironment, the impact of patient demographics, and the use of artificial intelligence to shape the future of this field.
期刊介绍：
APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities.
APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes:
-Biofabrication and Bioprinting
-Biomedical Materials, Sensors, and Imaging
-Engineered Living Systems
-Cell and Tissue Engineering
-Regenerative Medicine
-Molecular, Cell, and Tissue Biomechanics
-Systems Biology and Computational Biology
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
