{"title":"Acute promyelocytic leukemia complicated by osteofascial compartment syndrome.","authors":"Xiaojuan Li, Min Liu, Zhan Su, Xiaojun Zou","doi":"10.1080/17843286.2025.2606872","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Osteofascial compartment syndrome (OCS) refers to a series of clinical syndromes caused by acute ischemia and hypoxia of the tissues inside a fascial compartment. OCS secondary to acute leukemia is extremely rare. Coagulopathy is a common phenomenon in acute promyelocytic leukemia (APL), which often leads to various bleeding complications.</p><p><strong>Clinical presentation: </strong>We report the first case of APL complicated by OCS. The elderly female experienced differentiation syndrome, left forearm OCS, and rhabdomyolysis during the induction treatment. The coagulopathy ultimately resulted in a fatal cerebral hemorrhage.</p><p><strong>Conclusion: </strong>Compared to the more commonly reported OCS associated with chronic leukemias, OCS secondary to APL is particularly perilous.</p>","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"80-83"},"PeriodicalIF":0.9000,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Clinica Belgica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17843286.2025.2606872","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/12/21 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Osteofascial compartment syndrome (OCS) refers to a series of clinical syndromes caused by acute ischemia and hypoxia of the tissues inside a fascial compartment. OCS secondary to acute leukemia is extremely rare. Coagulopathy is a common phenomenon in acute promyelocytic leukemia (APL), which often leads to various bleeding complications.
Clinical presentation: We report the first case of APL complicated by OCS. The elderly female experienced differentiation syndrome, left forearm OCS, and rhabdomyolysis during the induction treatment. The coagulopathy ultimately resulted in a fatal cerebral hemorrhage.
Conclusion: Compared to the more commonly reported OCS associated with chronic leukemias, OCS secondary to APL is particularly perilous.
期刊介绍：
Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.
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