Inequalities in availability of clinical trials for pediatric, adolescent, and young adult patients with cancer in Europe: results from the SIOPE OCEAN project

IF 15.7 Q1 HEALTH CARE SCIENCES & SERVICES

Lancet Regional Health-Europe Pub Date : 2026-03-01 Epub Date: 2025-12-17 DOI:10.1016/j.lanepe.2025.101554

Kerstin K. Rauwolf , Teresa de Rojas , Miguel Martins , Maria Otth , Uta Dirksen , Delphine Heenen , Lejla Kameric , Pamela Kearns , Ruth Ladenstein , Cormac Owens , Caroline Queiroz , Richard Sullivan , Carmelo Rizzari , Gilles Vassal , European Society for Paediatric Oncology (SIOPE)

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引用次数: 0

Abstract

There are pronounced inequalities in outcomes of children, adolescents, and young adults (AYA) with cancer across Europe. The OCEAN project aimed at describing the availability of clinical trials for this population, the inequalities between countries, and propose solutions to reduce these disparities. The ClinicalTrials.gov database was searched to identify all European cancer clinical interventional studies including patients <18 years with a start date between 2010 and 2022. The study included 436 cancer-directed trials in 38 European countries. More than half were academic-sponsored (55%), and 49% included exclusively pediatric/AYA patients. Important differences in available trial numbers per country were identified, with more trials observed in Northern and Western Europe as compared to Eastern Europe. There is an urgent need to address differences in clinical trials availability both at European and national levels to advance equity and improve care, research and access to innovation for all pediatric/AYA patients with cancer in Europe.

Funding

This work has been performed as part of WP6 on inequalities in cancer research of the 4.UNCAN.eu Coordination and Support Action (#101069496) funded by the European Union and has been supported by Zoé4Life (MO).

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欧洲儿童、青少年和青年癌症患者临床试验可获得性的不平等：来自SIOPE OCEAN项目的结果

在欧洲，患有癌症的儿童、青少年和年轻人（AYA）的预后存在明显的不平等。OCEAN项目旨在描述针对这一人群的临床试验的可用性、国家之间的不平等，并提出减少这些不平等的解决方案。我们检索了ClinicalTrials.gov数据库，以确定所有欧洲癌症临床介入研究，包括开始日期在2010年至2022年之间的18岁患者。这项研究包括在38个欧洲国家进行的436项针对癌症的试验。超过一半是学术赞助的（55%），49%是儿科/AYA患者。各国现有试验数量存在重大差异，北欧和西欧的试验数量多于东欧。迫切需要解决欧洲和各国在临床试验可获得性方面的差异，以促进公平，改善欧洲所有儿科/AYA癌症患者的护理、研究和获得创新的途径。这项工作是联合国癌症研究中心癌症研究不平等问题第六工作组的一部分。欧盟协调和支持行动（#101069496）由欧洲联盟资助，并得到zosam4life （MO）的支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lancet Regional Health-Europe Multiple-

CiteScore

19.90

自引率

1.40%

发文量

260

审稿时长

9 weeks

期刊介绍： The Lancet Regional Health – Europe, a gold open access journal, is part of The Lancet's global effort to promote healthcare quality and accessibility worldwide. It focuses on advancing clinical practice and health policy in the European region to enhance health outcomes. The journal publishes high-quality original research advocating changes in clinical practice and health policy. It also includes reviews, commentaries, and opinion pieces on regional health topics, such as infection and disease prevention, healthy aging, and reducing health disparities.