{"title":"The roles of Tenascin C in kidney diseases.","authors":"Tim Caspers, Peter Boor, Barbara Mara Klinkhammer","doi":"10.1152/ajpcell.00514.2025","DOIUrl":null,"url":null,"abstract":"<p><p>Tenascin C (TNC), an extracellular matrix glycoprotein, is crucial for embryonic development and tissue repair, inflammation, extracellular matrix remodeling, and fibrosis, particularly in kidney diseases. Although its expression is typically low in healthy adult kidneys, TNC is upregulated in various kidney disease conditions, including acute kidney injury (AKI) and chronic kidney disease (CKD). TNC influences fibroblast activation, and elevated TNC levels correlate with CKD severity, highlighting its potential as a biomarker for diagnosis and monitoring of fibrogenesis. TNC's multifaceted role offers opportunities for therapeutic interventions. Here, we provide an overview of TNC's structural and functional attributes, its regulatory mechanisms, and its multifactorial role in kidney disease development and progression. We also discuss recent approaches aiming to use TNC as a target for diagnostic and therapeutic purposes.</p>","PeriodicalId":7585,"journal":{"name":"American journal of physiology. Cell physiology","volume":" ","pages":"C552-C569"},"PeriodicalIF":4.7000,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of physiology. Cell physiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1152/ajpcell.00514.2025","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/12/19 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Tenascin C (TNC), an extracellular matrix glycoprotein, is crucial for embryonic development and tissue repair, inflammation, extracellular matrix remodeling, and fibrosis, particularly in kidney diseases. Although its expression is typically low in healthy adult kidneys, TNC is upregulated in various kidney disease conditions, including acute kidney injury (AKI) and chronic kidney disease (CKD). TNC influences fibroblast activation, and elevated TNC levels correlate with CKD severity, highlighting its potential as a biomarker for diagnosis and monitoring of fibrogenesis. TNC's multifaceted role offers opportunities for therapeutic interventions. Here, we provide an overview of TNC's structural and functional attributes, its regulatory mechanisms, and its multifactorial role in kidney disease development and progression. We also discuss recent approaches aiming to use TNC as a target for diagnostic and therapeutic purposes.
Tenascin C （TNC）是一种细胞外基质糖蛋白，对胚胎发育和组织修复、炎症、细胞外基质重塑和纤维化，特别是肾脏疾病至关重要。虽然其在健康成人肾脏中的表达通常较低，但TNC在各种肾脏疾病（包括急性肾损伤（AKI）和慢性肾脏疾病（CKD））中表达上调。TNC影响成纤维细胞活化，TNC水平升高与CKD严重程度相关，突出了其作为诊断和监测纤维发生的生物标志物的潜力。跨国公司的多方面作用为治疗干预提供了机会。在这里，我们提供TNC的结构和功能属性，其调控机制，及其在肾脏疾病发生和进展中的多因素作用的概述。我们还讨论了最近旨在使用TNC作为诊断和治疗目的的靶点的方法。
期刊介绍：
The American Journal of Physiology-Cell Physiology is dedicated to innovative approaches to the study of cell and molecular physiology. Contributions that use cellular and molecular approaches to shed light on mechanisms of physiological control at higher levels of organization also appear regularly. Manuscripts dealing with the structure and function of cell membranes, contractile systems, cellular organelles, and membrane channels, transporters, and pumps are encouraged. Studies dealing with integrated regulation of cellular function, including mechanisms of signal transduction, development, gene expression, cell-to-cell interactions, and the cell physiology of pathophysiological states, are also eagerly sought. Interdisciplinary studies that apply the approaches of biochemistry, biophysics, molecular biology, morphology, and immunology to the determination of new principles in cell physiology are especially welcome.
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