Secreted frizzled-related proteins in angiogenesis: molecular mechanisms and clinical implications

IF 11.2 1区医学 Q1 PERIPHERAL VASCULAR DISEASE

Angiogenesis Pub Date : 2025-12-19 DOI:10.1007/s10456-025-10024-6

Wei Wu, Yukun Zhang, Weihua Song, David Virshup, Xiaomeng Wang

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引用次数: 0

Abstract

Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is essential for tissue homeostasis, development, and repair. Dysregulation of this tightly regulated process contributes to a wide range of diseases, including cancer, ischemic disorders, and chronic inflammatory conditions. This review focuses on the secreted frizzled-related protein (SFRP) family, a group of pivotal yet underappreciated regulators of neovascularization. We discuss the tissue-specific expression patterns, regulatory mechanisms, and functional roles of SFRPs in both physiological and pathological vascular remodeling. Particular attention is given to their interactions with key signaling pathways, including Wnt, highlighting their context-dependent effects on angiogenesis. Drawing on extensive preclinical evidence, we position SFRPs as novel regulators of vascular remodeling and explore their potential as promising targets for therapeutic intervention. This comprehensive analysis underscores the importance of further mechanistic and clinical studies to unlock the therapeutic potential of SFRPs in vascular pathologies.

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血管生成中分泌卷曲相关蛋白：分子机制和临床意义

血管生成，即从已有的血管系统中形成新血管，对组织稳态、发育和修复至关重要。这种严格调控过程的失调导致了广泛的疾病，包括癌症、缺血性疾病和慢性炎症。这篇综述的重点是分泌卷曲相关蛋白（SFRP）家族，这是一组关键但未被充分认识的新血管形成调节因子。我们讨论了SFRPs在生理和病理血管重构中的组织特异性表达模式、调节机制和功能作用。特别关注它们与关键信号通路的相互作用，包括Wnt，强调它们对血管生成的环境依赖性作用。根据广泛的临床前证据，我们将SFRPs定位为血管重塑的新型调节剂，并探索其作为治疗干预的有希望靶点的潜力。这项综合分析强调了进一步的机制和临床研究的重要性，以解锁血管病变中SFRPs的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angiogenesis PERIPHERAL VASCULAR DISEASE-

CiteScore

21.90

自引率

8.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Angiogenesis, a renowned international journal, seeks to publish high-quality original articles and reviews on the cellular and molecular mechanisms governing angiogenesis in both normal and pathological conditions. By serving as a primary platform for swift communication within the field of angiogenesis research, this multidisciplinary journal showcases pioneering experimental studies utilizing molecular techniques, in vitro methods, animal models, and clinical investigations into angiogenic diseases. Furthermore, Angiogenesis sheds light on cutting-edge therapeutic strategies for promoting or inhibiting angiogenesis, while also highlighting fresh markers and techniques for disease diagnosis and prognosis.