Enhancing data compatibility in an evolving landscape: Medical cannabis and polysubstance use protocols in the PhenX Toolkit

IF 3.5 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI:10.1016/j.drugalcdep.2025.113001

Anne Buu , Johannes Thrul , Amanda Bunting , Tamara Haegerich , Wayne Huggins , Christian Hopfer , Denise Vidot , Cataia Ives , Ryan McNeil , Sarah Zemore , Corrie Vilsaint , Elizabeth Fallon , Christine Hill , Carol Hamilton , John Kelly

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引用次数: 0

Abstract

Introduction

With increasing legalization of medical cannabis and prevalence of polysubstance use in the United States comes the need for standard psychometrically validated measures to study these substances’ health effects in the population. The PhenX (consensus measures for Phenotypes and eXposures) Toolkit (www.phenxtoolkit.org) is a freely accessible catalog of recommended measurement protocols to promote data compatibility across studies, but this extensive catalog did not include measures in these important areas.

Methods

In 2024, a PhenX Working Group of experts followed a well-established consensus process to identify and recommend measurement protocols suitable for inclusion in studies on medical cannabis and polysubstance use. The broader scientific community was invited to review and provide feedback that was considered in the process of finalizing recommendations.

Results

In 2025, the PhenX Toolkit released 15 new medical cannabis and polysubstance use protocols, which assess medical and other cannabis use—including consumption levels, product types, sources, motives, expectancies, medical card status, provider–patient communication, and biochemical validation—as well as polysubstance use patterns and related overdose risk. These protocols complement existing substance-related content in PhenX Toolkit and facilitate future development of knowledge on health effects of cannabis and polysubstance use and clinical guidance on safety or dosing for medical cannabis.

Conclusion

Researchers are encouraged to adopt these measurement protocols, so results across studies can be better compared and combined to efficiently and reliably evaluate the health effects of medical cannabis and polysubstance use. Measures in these domains will continue to be updated as new knowledge is gained.

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在不断发展的环境中增强数据兼容性：PhenX工具包中的医用大麻和多物质使用协议。

导言：随着医用大麻的日益合法化和多物质使用在美国的普遍存在，需要标准的心理测量学验证措施来研究这些物质对人口健康的影响。PhenX（表型和暴露的共识测量）工具包（www.phenxtoolkit.org）是一个免费访问的推荐测量方案目录，以促进研究之间的数据兼容性，但这个广泛的目录不包括这些重要领域的测量。方法：2024年，一个PhenX专家工作组遵循了一个完善的共识过程，以确定和推荐适合纳入医用大麻和多物质使用研究的测量方案。更广泛的科学界被邀请审查并提供反馈，这些反馈在最后确定建议的过程中得到了考虑。结果：2025年，PhenX工具包发布了15个新的医用大麻和多物质使用方案，评估了医用和其他大麻的使用情况，包括消费水平、产品类型、来源、动机、预期、医疗卡状态、提供者-患者沟通和生化验证，以及多物质使用模式和相关的过量风险。这些议定书补充了PhenX工具包中现有的与物质有关的内容，并促进了关于大麻和多物质使用对健康影响的知识的未来发展，以及关于医用大麻安全性或剂量的临床指导。结论：鼓励研究人员采用这些测量方案，以便更好地比较和综合各项研究的结果，以有效和可靠地评估医用大麻和多物质使用对健康的影响。这些领域的措施将随着获得新知识而不断更新。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug and alcohol dependence 医学-精神病学

CiteScore

7.40

自引率

7.10%

发文量

409

审稿时长

41 days

期刊介绍： Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.