Uterine transposition for fertility preservation in extra-skeletal ewing sarcoma: the first French case report

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of gynecology obstetrics and human reproduction Pub Date : 2026-02-01 Epub Date: 2025-12-15 DOI:10.1016/j.jogoh.2025.103088

Cherif Akladios , Thomas Boisramé , Camille Martel , Djanagane Mounien , Guillaume Henry , Georges Noël , Laure Waeldin , Mathilde Lapointe , Marie Lorho , Marie-Liesse Paty , Eva Fuss , Floriane Jochum , Lise Lecointre

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引用次数: 0

Abstract

We present the first French case of uterine transposition for fertility preservation in a 25-year-old nulligravida patient with rectovaginal extra-skeletal Ewing sarcoma. After receiving induction chemotherapy, the uterus was transposed to the upper abdomen via laparotomy. During the same procedure, a posterior pelvectomy was performed to achieve wide surgical margins for tumor removal. To mitigate digestive toxicity from subsequent pelvic radiotherapy, a breast expansion prosthesis was placed. The patient experienced regular menstruation postoperatively, indicating preserved uterine function. After completing radiochemotherapy, we successfully repositioned the uterus into the pelvis. Menstruation resumed within months of reimplantation, and a clinical examination revealed a normal-appearing cervix. This case demonstrates the feasibility and potential benefits of uterine transposition for preserving fertility in women with pelvic malignancies who require radiotherapy. Further research is needed to evaluate the long-term outcomes and reproductive potential of this procedure.

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子宫移位保存骨外尤文氏肉瘤的生育能力：法国首例病例报告。

我们提出的第一例法国病例子宫移位为生育能力保存在25岁的无阴道患者直肠阴道骨外尤因肉瘤。接受诱导化疗后，经剖腹手术将子宫移至上腹部。在相同的手术过程中，进行了骨盆后切除术以获得更宽的手术切缘以切除肿瘤。为了减轻随后盆腔放疗的消化毒性，放置乳房扩张假体。患者术后月经正常，子宫功能保持正常。在完成放化疗后，我们成功地将子宫重新定位到骨盆内。月经在移植后几个月内恢复，临床检查显示子宫颈外观正常。本病例证明子宫移位对需要放疗的盆腔恶性肿瘤患者保留生育能力的可行性和潜在益处。需要进一步的研究来评估这种手术的长期结果和生殖潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of gynecology obstetrics and human reproduction Medicine-Obstetrics and Gynecology

CiteScore

3.70

自引率

5.30%

发文量

210

审稿时长

31 days

期刊介绍： Formerly known as Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Journal of Gynecology Obstetrics and Human Reproduction is the official Academic publication of the French College of Obstetricians and Gynecologists (Collège National des Gynécologues et Obstétriciens Français / CNGOF). J Gynecol Obstet Hum Reprod publishes monthly, in English, research papers and techniques in the fields of Gynecology, Obstetrics, Neonatology and Human Reproduction: (guest) editorials, original articles, reviews, updates, technical notes, case reports, letters to the editor and guidelines. Original works include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses.