Mohammad Al-Zubi, Rana Haddad, Ammar Badr, Hayat Al Bibi, Saif Azzam, Mohammad Araydah, Ahmed Al Sharie, Karis Khattab, Hussein Qasim, Sarah Al Sharie
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引用次数: 0
Abstract
Background: Renal cell carcinoma (RCC) is the most common adult kidney malignancy, yet regional data from the Middle East are limited. This study characterized the clinicopathological, immunohistochemical, and survival features of RCC in a Jordanian cohort.
Methods: A retrospective analysis of 295 RCC cases (2020-2024) from Yarmouk University affiliated hospitals was conducted. Clinical and pathological parameters, immunohistochemical markers, and survival were analyzed using Kaplan-Meier and log-rank tests.
Results: Clear-cell RCC was the predominant subtype (72.2%), followed by papillary (10.5%), chromophobe (9.1%), and others (8.1%). The mean age was 62.1 years, with male predominance (66.4%). Clear-cell RCC showed higher rates of high-grade histology, sarcomatoid and rhabdoid differentiation, capsule invasion, renal vein involvement, and metastasis (p < 0.05), while chromophobe RCC was indolent with no metastases. CK7, Hale's iron, and c-kit characterized chromophobe RCC, vimentin was typical of clear-cell, and AMACR of papillary RCC. Survival was significantly worse with older age, higher T stage, sarcomatoid features, and higher ISUP grade, while nephrectomy type had no effect.
Conclusions: Clear-cell RCC demonstrated aggressive pathology, whereas chromophobe RCC was indolent. Age, subtype, stage, and sarcomatoid features were key prognostic factors, highlighting the need for early detection and expanded nephron-sparing surgery in the region.
期刊介绍：
Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries
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