Recent Stress Potentiation and Paralimbic System Reactivity in Young Adults With Bipolar Disorder: Implications for Suicide Risk and Effects of Cannabis Use Disorder

IF 4.9 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Pub Date : 2026-06-01 Epub Date: 2025-12-13 DOI:10.1016/j.bpsc.2025.12.002

Nadia Bibb , Kait Meek , Raquel Kosted , Skyler Lee , Jorge R.C. Almeida , Elizabeth T.C. Lippard

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引用次数: 0

Abstract

Background

Bipolar disorder coincides with one of the highest rates of suicide among all psychiatric conditions. Individual differences in stress reactivity may contribute to increased susceptibility to suicide-related thoughts and behaviors (STBs). Research examining the stress response and its relationship with STBs in bipolar disorder is limited. The purpose of this study was to investigate associations between recent perceived stress and neurophysiological response to acute psychosocial stress in anterior-paralimbic system in young adults with bipolar disorder with and without a suicide attempt history.

Methods

Seventy-two young adults (21 with bipolar disorder and a history of suicide attempt(s) [BD-SA], 22 diagnostic control participants without a suicide attempt history [BD-noSA], and 29 typically developing [TD] individuals) were assessed for past-month perceived stress (Perceived Stress Scale [PSS]) and completed a functional magnetic resonance imaging Stress Math Task. Stress-related functional changes in anterior-paralimbic regions of interest were examined in relation to PSS scores. Effects of lifetime alcohol/cannabis use disorder and nicotine use on stress reactivity were explored.

Results

In the BD-SA group, recent perceived stress was associated with greater reactivity to psychosocial stress in the medial orbitofrontal cortex, anterior insula, amygdala, and anterior cingulate cortex (group-by-PSS interactions: ps ≤ .008). These patterns were not observed in the BD-noSA or TD groups. Lifetime cannabis use disorder and recent nicotine use were related to greater anterior-paralimbic responses to stress in bipolar disorder (ps ≤ .002).

Conclusions

Heightened anterior-paralimbic reactivity to cumulative stress may represent a risk factor for STBs. Cannabis and nicotine use may exacerbate stress-related anterior-paralimbic dysregulation. Future longitudinal research is needed to extend findings and investigate temporal relationships between stress reactivity, cannabis/nicotine use, and STBs.

查看原文本刊更多论文

最近的压力增强和副边缘系统反应在青年双相情感障碍：暗示自杀风险和大麻使用障碍的影响。

背景：双相情感障碍是所有精神疾病中自杀率最高的疾病之一。压力反应的个体差异可能会增加自杀相关想法和行为的易感性。双相情感障碍患者的应激反应及其与性传播感染的关系的研究是有限的。本研究的目的是调查有或没有自杀企图史的年轻双相情感障碍患者前旁边缘系统近期感知压力与急性心理社会压力的神经生理反应之间的关系。方法：对72名年轻成人（22名患有双相情感障碍并有自杀企图史[BD-SA]， 21名无自杀企图史的诊断对照[BD-noSA]， 29名典型发展[TD]）进行过去一个月的感知应激（PSS）评估，并完成fMRI应激数学任务。我们检查了与PSS相关的前边缘旁区应力相关的功能变化。探讨终身酒精/大麻使用障碍和尼古丁使用对应激反应的影响。结果：在BD-SA的年轻人中，近期感受到的压力与内侧眶额皮质、前脑岛、杏仁核和前扣带皮层对社会心理压力的反应性增强有关(组- pss相互作用：p’s结论：前边缘对累积压力的反应性增强可能是STBs的一个危险因素。大麻和尼古丁的使用可能会加剧与压力相关的前边缘失调。未来的纵向研究需要扩展研究结果，并调查应激反应、大麻/尼古丁使用和性传播感染之间的时间关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Neuroscience-Biological Psychiatry

CiteScore

10.40

自引率

1.70%

发文量

247

审稿时长

30 days

期刊介绍： Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is an official journal of the Society for Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal focuses on studies using the tools and constructs of cognitive neuroscience, including the full range of non-invasive neuroimaging and human extra- and intracranial physiological recording methodologies. It publishes both basic and clinical studies, including those that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The journal publishes novel results of original research which represent an important new lead or significant impact on the field. Reviews and commentaries that focus on topics of current research and interest are also encouraged.