Multidelay Pseudocontinuous Arterial Spin Labelling and Conventional Single-delay Pseudocontinuous Arterial Spin Labelling In Nasopharyngeal Carcinoma: Correlation with Dynamic Contrast-enhanced Magnetic Resonance Imaging

IF 2.5 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Seminars in Ultrasound Ct and Mri Pub Date : 2026-02-01 Epub Date: 2025-10-25 DOI:10.1053/j.sult.2025.10.004

Tongtong Tian , liqin Liu , Jun Sun , Jianxiong Fu , Xianfu Luo , Jing Ye , Guangyu Tang

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Abstract

The purpose of this prospective study was to investigate the potential correlations among three perfusion methods—multidelay pseudocontinuous arterial spin labelling (MD-PCASL), conventional single-delay pseudocontinuous arterial spin labelling (SD-PCASL), and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)—in patients with locoregionally advanced nasopharyngeal carcinoma (ANPC). Forty-seven patients with locoregional ANPC were prospectively recruited. Two observers independently calculated the MD-PCASL parameters, including the ATT-corrected tumour blood flow (c-TBF), arterial transit time (ATT), and arterial tumour blood volume (aTBV); the SD-PCASL parameters, including the noncorrected tumour blood flow (nc-TBF); and the DCE-MRI quantitative parameters, including K^trans, K_ep, V_e, and V_p. The intra- and interobserver agreement was evaluated via the intraclass correlation coefficient (ICC) and BlandAltman analysis. Relationships between the MD-PCASL, SD-PCASL and DCE-MRI parameters were assessed via Spearman’s rank correlation. The intra- and interobserver reproducibility were excellent, with ICCs ranging from 0.81 to 0.997 and a narrow width of 95% limits of agreement. A good positive correlation was observed between MD-PCASL-related perfusion parameters (c-TBF, aTBV) and DCE-MRI parameters (K^trans, K_ep) (Spearman’s rank correlation coefficients: 0.61 to 0.71, p < 0.001). The SD-PCASL (nc-TBF) values were fairly correlated with K^trans (p<0.001, r = 0.53) and K_ep (p<0.001, r=0.51). In addition, there was a good correlation between the MD-PCASL-related perfusion parameters (c-TBF) and the SD-PCASL parameters (nc-TBF) (Spearman’s rank correlation coefficients: 0.70, p < 0.001). No correlation was detected between MD-PCASL-related perfusion parameters (c-TBF and aTBV), SD-PCASL (nc-TBF) and DCE-MRI parameters (V_e and V_p) (Spearman’s rank correlation coefficients: 0.07 to 0.145, p > 0.05). MD-PCASL multiparametric perfusion, SD-PCASL single-parameter perfusion and quantitative DCE-MRI parameters were correlated and reproducible in the assessment of ANPC. Although SD-PCASL demonstrated a fair correlation with DCE-MRI, the correlation was inferior to that of MD-PCASL with multiple parameters. MD-PCASL, as a noninvasive perfusion imaging tool, may become an alternative for assessing ANPC perfusion levels in the future.

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鼻咽癌的多延迟假连续动脉自旋标记和常规单延迟假连续动脉自旋标记：与动态磁共振增强成像的相关性。

本前瞻性研究的目的是探讨三种灌注方法——多延迟假连续动脉自旋标记（MD-PCASL）、常规单延迟假连续动脉自旋标记（SD-PCASL）和动态对比增强磁共振成像（DCE-MRI）在局部区域晚期鼻咽癌（ANPC）患者中的潜在相关性。前瞻性招募47例局部区域性ANPC患者。两名观察员独立计算MD-PCASL参数，包括at校正的肿瘤血流量（c-TBF）、动脉运输时间（ATT）和动脉肿瘤血容量（aTBV）；SD-PCASL参数，包括未校正肿瘤血流（nc-TBF）；DCE-MRI定量参数，包括Ktrans、Kep、Ve、Vp。通过类内相关系数（ICC）和BlandAltman分析来评估观察者内部和观察者之间的一致性。通过Spearman秩相关评估MD-PCASL、SD-PCASL与DCE-MRI参数之间的关系。观察者内部和观察者之间的重现性非常好，ICCs范围为0.81 ~ 0.997，一致性限窄至95%。md - pcasl相关灌注参数（c-TBF、aTBV）与DCE-MRI参数（Ktrans、Kep）呈良好的正相关（Spearman秩相关系数：0.61 ~ 0.71,p < 0.001）。SD-PCASL （nc-TBF）值与Ktrans （pep (pe和Vp)）呈正相关（Spearman等级相关系数：0.07 ~ 0.145,p < 0.05）。MD-PCASL多参数灌注、SD-PCASL单参数灌注与定量DCE-MRI参数评价ANPC具有相关性和可重复性。SD-PCASL与DCE-MRI的相关性较好，但与多参数的MD-PCASL的相关性较差。MD-PCASL作为一种无创灌注成像工具，未来可能成为评估ANPC灌注水平的替代方法。

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来源期刊

Seminars in Ultrasound Ct and Mri 医学-核医学

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Ultrasound, CT and MRI is directed to all physicians involved in the performance and interpretation of ultrasound, computed tomography, and magnetic resonance imaging procedures. It is a timely source for the publication of new concepts and research findings directly applicable to day-to-day clinical practice. The articles describe the performance of various procedures together with the authors'' approach to problems of interpretation.