{"title":"Improving perinatal outcomes: A review of landmark trials that have changed obstetric practice","authors":"Mary Marchese, Victoria Adewale, Dwight J. Rouse","doi":"10.1016/j.semperi.2025.152208","DOIUrl":null,"url":null,"abstract":"<div><div>Over the past few decades, multiple landmark studies investigating interventions for perinatal benefit have determined best practices for obstetricians worldwide. In this review, we will highlight trials that have demonstrated the effects of maternal intervention for perinatal benefit, including latency antibiotics, antenatal steroids, fetal neuroprotective measures, intrapartum group B streptococcus (GBS) prophylaxis, and delivery timing.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"50 3","pages":"Article 152208"},"PeriodicalIF":3.2000,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in perinatology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0146000525001855","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/12/13 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Over the past few decades, multiple landmark studies investigating interventions for perinatal benefit have determined best practices for obstetricians worldwide. In this review, we will highlight trials that have demonstrated the effects of maternal intervention for perinatal benefit, including latency antibiotics, antenatal steroids, fetal neuroprotective measures, intrapartum group B streptococcus (GBS) prophylaxis, and delivery timing.
期刊介绍:
The purpose of each issue of Seminars in Perinatology is to provide authoritative and comprehensive reviews of a single topic of interest to professionals who care for the mother, the fetus, and the newborn. The journal''s readership includes perinatologists, obstetricians, pediatricians, epidemiologists, students in these fields, and others. Each issue offers a comprehensive review of an individual topic, with emphasis on new developments that will have a direct impact on their practice.