Temporal trends in diabetes mellitus type 2 and sepsis-related mortality among U.S. adults: a 22-year analysis.

IF 2.1 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes and Metabolic Disorders Pub Date : 2025-12-11 eCollection Date: 2025-12-01 DOI:10.1007/s40200-025-01781-8

Fatima Naveed, Inshal Uddin Khattak, Aqsa Hafeez, Abdullah Imtiaz, Bisma Naz, Rubbia Sabir, Syed Abdul Aziz Jameel, Nikil Kumar, Ambreen Hamid, Sunny Kumar, Rahat Un Nisa, Kehan Ali Rizvi, Priya Rani

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引用次数: 0

Abstract

Background: Diabetes mellitus (DM) type 2, the most prevalent form of diabetes, is affecting a population of 460 million worldwide. Individuals with diabetes are at a higher risk of developing sepsis which can be lethal if not managed properly. This study aims to analyse the trends in mortality due to diabetes mellitus type 2 and sepsis in the United States between 1999 and 2020.

Methods: Death certificate data from the CDC WONDER database was retrospectively analysed from 1999 to 2020 for mortality due to DM type 2 and sepsis in the adult population using ICD-10 codes. Age-adjusted mortality rates (AAMRs) obtained were stratified by year, sex, race/ethnicity, age, location of death, urbanization and census region. The Joinpoint regression programme was then used to calculate Annual Percentage Change (APC).

Results: 109,094 DM type 2 and sepsis-related deaths were reported among adults of United States from 1999 to 2020 with an overall AAMR of 2.29 (95% CI: 2.28-2.31). The overall AAMR was higher in males (2.61; 95% CI: 2.58-2.63) than in females (2.05; 95% CI: 2.03-2.07). Geographically, the mortality rates were higher in the Western region (3.05; 95% CI: 3.02-3.09). Similarly, the AAMRs for non-metropolitan areas were consistently higher than those of metropolitan areas. Stratification by race/ethnicities showed that NH American Indians/Alaska Natives had the highest AAMR (5.09, 95% CI: 4.80-5.37) while the lowest was observed in NH Whites (1.88, 95% CI: 1.87-1.90). Most deaths occurred at medical facilities (77.45%).

Conclusion: Males, older adults, NH American Indians, non-metropolitan areas and Western region were associated with higher DM type 2 and sepsis-related mortality, which is concerning. This study has brought light on the need for strategies and interventions to reduce the impact of sepsis on the population having DM type 2. Further research is necessary to identify effective strategies for prevention, early detection, and management of sepsis in this high-risk population.

Supplementary information: The online version contains supplementary material available at 10.1007/s40200-025-01781-8.

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美国成年人2型糖尿病和败血症相关死亡率的时间趋势：一项22年分析

背景：2型糖尿病（DM）是最常见的糖尿病形式，影响着全球4.6亿人口。糖尿病患者患败血症的风险更高，如果处理不当，败血症可能是致命的。本研究旨在分析1999年至2020年间美国2型糖尿病和败血症的死亡率趋势。方法：使用ICD-10代码对1999年至2020年CDC WONDER数据库中的死亡证明数据进行回顾性分析，分析成人中2型糖尿病和败血症的死亡率。获得的年龄调整死亡率（AAMRs）按年份、性别、种族/民族、年龄、死亡地点、城市化和人口普查区域分层。然后使用连接点回归程序计算年变化百分比（APC）。结果：1999年至2020年，美国成年人中报告了109,094例2型糖尿病和败血症相关死亡，总体AAMR为2.29 （95% CI: 2.28-2.31）。男性的总体AAMR （2.61, 95% CI: 2.58-2.63）高于女性（2.05,95% CI: 2.03-2.07）。从地理上看，西部地区的死亡率较高（3.05;95% CI: 3.02-3.09）。同样，非大都市地区的aamr也始终高于大都市地区。种族/民族分层显示，NH美洲印第安人/阿拉斯加原住民的AAMR最高（5.09,95% CI: 4.80-5.37），而NH白人的AAMR最低（1.88,95% CI: 1.87-1.90）。大多数死亡发生在医疗设施（77.45%）。结论：男性、老年人、NH美洲印第安人、非大都市地区和西部地区与较高的2型糖尿病和败血症相关死亡率相关，值得关注。这项研究揭示了需要采取策略和干预措施来减少败血症对2型糖尿病患者的影响。进一步的研究是必要的，以确定有效的策略，预防，早期发现和管理败血症在这一高危人群。补充资料：在线版本提供补充资料，网址为10.1007/s40200-025-01781-8。

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来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.