High-grade gliomas derived from an ovarian mature teratoma: clonal dynamics and genetic insights.

IF 0.4 Q4 ONCOLOGY

International Cancer Conference Journal Pub Date : 2025-09-08 eCollection Date: 2025-10-01 DOI:10.1007/s13691-025-00790-x

Kota Yamauchi, Junzo Hamanishi, Koichi Watanabe, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Hiroyuki Katsuragawa, Koji Yamanoi, Takashi Motohashi, Yuko Hosoe, Ken Yamaguchi, Kiyoshi Yamaguchi, Seiya Imoto, Tsutomu Tabata, Yoichi Furukawa, Yohei Mineharu, Yoshiki Arakawa, Seishi Ogawa, Sachiko Minamiguchi, Masaki Mandai

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引用次数: 0

Abstract

High-grade glioma (HGG) arising from a mature ovarian teratoma is extremely rare and its genetic alterations remain largely unknown. We report a case of WHO Grade 4 HGG (HGG-G4) developing 3 years after cystectomy for ovarian mature teratoma, where a WHO Grade 3 HGG (HGG-G3) was identified upon pathological reevaluation. Whole-exome sequencing confirmed the clonal relationship between HGG-G3 and HGG-G4, revealing genome-wide copy-neutral loss of heterozygosity, copy-number alterations, and whole-genome doubling in both HGGs. Genomic and epigenetic analyses have suggested multistep tumorigenesis and clonal alteration during the clinical course, particularly in response to chemotherapy, in HGGs arising from ovarian teratomas.

Supplementary information: The online version contains supplementary material available at 10.1007/s13691-025-00790-x.

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源自卵巢成熟畸胎瘤的高级别胶质瘤：克隆动力学和遗传学见解。

由成熟卵巢畸胎瘤引起的高级别胶质瘤（HGG）极为罕见，其遗传改变在很大程度上仍然未知。我们报告一例世卫组织4级HGG （HGG- g4）在卵巢成熟畸胎瘤膀胱切除术后3年发生，经病理重新评估确定为世卫组织3级HGG （HGG- g3）。全外显子组测序证实了HGG-G3和HGG-G4之间的克隆关系，揭示了这两种hgg全基因组的拷贝中性杂合性缺失、拷贝数改变和全基因组加倍。基因组学和表观遗传学分析表明，卵巢畸胎瘤引起的hgg在临床过程中，特别是在对化疗的反应中，发生了多步骤的肿瘤发生和克隆改变。补充信息：在线版本包含补充资料，提供地址为10.1007/s13691-025-00790-x。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Cancer Conference Journal ONCOLOGY-

自引率

14.30%

发文量

期刊介绍： This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)