Multilayered regulation of longevity in Caenorhabditis elegans

IF 8.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules and Cells Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI:10.1016/j.mocell.2025.100308

Dajeong Bong , Hyunwoo C. Kwon , Seung-Jae V. Lee

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引用次数: 0

Abstract

Aging in Caenorhabditis elegans is regulated by evolutionarily conserved pathways that coordinate cellular maintenance and systemic homeostasis. Here, we review recent advances on four major longevity regimens, including reduced insulin/insulin-like growth factor 1 signaling (IIS), dietary restriction (DR), mild inhibition of mitochondrial respiration, and germline deficiency. Each longevity-promoting regimen enhances protein and RNA quality control, metabolic remodeling, and stress resistance to delay functional declines with age. Reduced IIS strengthens proteostasis and RNA surveillance. DR remodels metabolism and activates autophagy. Mild mitochondrial inhibition elicits adaptive redox signaling and quality control responses. Germline deficiency links reproductive cues to somatic maintenance. We highlight that longevity arises from the integrated regulation of transcriptional, metabolic, and inter-tissue signaling networks. Our review will provide valuable insights obtained from C. elegans into the conserved mechanisms of aging, facilitating the development of interventions that promote healthy longevity in humans.

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秀丽隐杆线虫长寿的多层调控。

秀丽隐杆线虫的衰老是由协调细胞维持和系统稳态的进化保守途径调节的。在这里，我们回顾了四种主要的长寿方案的最新进展，包括减少胰岛素/胰岛素样生长因子1信号（IIS）、饮食限制（DR）、轻度抑制线粒体呼吸和种系缺乏。每一种长寿疗法都能增强蛋白质和RNA质量控制、代谢重塑和抗应激能力，以延缓功能随年龄增长而衰退。降低IIS可增强蛋白质抑制和RNA监视。DR重塑代谢，激活自噬。轻度线粒体抑制引发适应性氧化还原信号和质量控制反应。种系缺陷将生殖线索与体细胞维持联系起来。我们强调，长寿源于转录、代谢和组织间信号网络的综合调控。我们的综述将为秀丽隐杆线虫的保守衰老机制提供有价值的见解，促进促进人类健康长寿的干预措施的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecules and Cells 生物-生化与分子生物学

CiteScore

6.60

自引率

10.50%

发文量

审稿时长

2.3 months

期刊介绍： Molecules and Cells is an international on-line open-access journal devoted to the advancement and dissemination of fundamental knowledge in molecular and cellular biology. It was launched in 1990 and ISO abbreviation is "Mol. Cells". Reports on a broad range of topics of general interest to molecular and cell biologists are published. It is published on the last day of each month by the Korean Society for Molecular and Cellular Biology.