Electrophysiological and histological study of synaptic connections between lateral geniculate transplant and host visual cortex.

T Hamasaki, K Hirakawa, K Toyama
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引用次数: 1

Abstract

The lateral geniculate nucleus (LGN) of fetal Wistar rats was transplanted to the visual cortex (VC) of 33 neonatal Wistar rats. Histological examination showed transplanted cells in all the host brains. Intensively labeled cells were demonstrated in the transplant by labeling with true blue. Electrophysiological studies with brain slice preparations demonstrated that the transplanted LGN sent axons and made excitatory monosynaptic connections mainly in layer IV of the VC area 17. Corticogeniculate projections were also demonstrated in the transplanted LGN.

侧膝状移植物与宿主视觉皮层突触连接的电生理和组织学研究。
将胎儿Wistar大鼠膝状外侧核(LGN)移植到33只新生Wistar大鼠视觉皮层(VC)。组织学检查显示所有宿主脑内均有移植细胞。用真蓝色标记显示移植细胞中密集标记的细胞。脑切片电生理研究表明,移植后的LGN主要在VC区第4层发送轴突并建立兴奋性单突触连接17。在移植的LGN中也发现了糖皮质原状突起。
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