Baseline characteristics of people living with HIV with different CD4(+) T cell depletion.

Abstract

HIV-1 infection can easily cause CD4(+) T cell depletion. To investigate the impact of CD4(+) T cell depletion on the health of people living with HIV-1 (PLWH), we collected and analyzed baseline data from 5139 volunteers who had never received any treatment. The results showed that as CD4(+) T cells were depleted, the volunteers were more likely to suffer from anemia, liver and kidney dysfunction, and blood glucose abnormalities, which were more pronounced in elderly PLWHs. In addition, there was a low correlation between dyslipidemia and CD4(+) depletion. CD4(+) T cell depletion increases the likelihood of HIV-1 carriers developing anemia, liver and kidney dysfunction, and blood glucose abnormalities, making elderly PLWHs more susceptible to these effects. Relatively speaking, the correlation between dyslipidemia and CD4(+) depletion is low.