Natural product inspired antibiotics approved for human use – 1943 to 2025

IF 12.5 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2026-05-27 Epub Date: 2025-12-11 DOI:10.1039/d5np00067j

Mark S. Butler , Robert J. Capon

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Abstract

Covering literature to September 2025

This review provides a comprehensive account of the 217 natural product inspired antibiotics that have been approved for human use from 1943 through to September 2025, inclusive of 52 (24%) that are natural products (NPs) and 165 (76%) that are semi-synthetic or synthetic derivatives of natural products (NP-Ds). These are organized into sixteen categories defined by shared structural motifs and, in many cases, common mechanisms of action. Each antibiotic is classified as either a NP or NP-D, annotated by a molecular structure that, where relevant, highlights the relationships between NPs and NP-Ds. Market details are also provided, including the company that brought each antibiotic to market, the year and country of first approval, the spectrum of usage across pathogen classes, routes of administration, current status, and selected commentary on mechanisms of action. The assembled dataset is further analysed through a series of charts that illustrate insightful trends that document the remarkable history and lasting impact of NP inspired antibiotics. The review concludes with observations on the historic impact and future prospects of natural products as a source of inspiration for the development of new generations of antibiotics.

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天然产品启发抗生素批准用于人类使用- 1943年至2025年。

本综述全面分析了1943年至2025年9月批准用于人用的217种天然产物启发抗生素，其中52种（24%）为天然产物（NPs）， 165种（76%）为半合成或天然产物的合成衍生物（NP-Ds）。它们被分为16类，由共同的结构主题和许多情况下共同的作用机制来定义。每种抗生素被分类为NP或NP- d，并由分子结构注释，在相关的情况下，突出了NP和NP- d之间的关系。还提供了市场细节，包括将每种抗生素推向市场的公司、首次批准的年份和国家、跨病原体类别的使用范围、给药途径、现状以及对作用机制的精选评论。通过一系列图表进一步分析组装的数据集，这些图表说明了深刻的趋势，记录了NP启发的抗生素的非凡历史和持久影响。本综述总结了天然产物作为新一代抗生素开发灵感来源的历史影响和未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.