Evaluating the Efficiency and Tooth Sensitivity of a Novel Whitening Strip: A Randomized, Double-Blind Controlled Trial

IF 4.6 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Esthetic and Restorative Dentistry Pub Date : 2026-08-13 Epub Date: 2025-12-08 DOI:10.1111/jerd.70070

Rui-xin Chen, Yu-jie Lan, Li Guo, Xin-yi Zhang, De-qin Yang

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引用次数: 0

Abstract

Objective

This randomized controlled clinical trial was to evaluate the tooth whitening efficacy and tooth sensitivity of a novel whitening strips with 3% hydrogen peroxide and 1.5% potassium nitrate.

Materials and Methods

Ninety six participants were randomly assigned into two groups: an experimental group using LESENING Whitening Strips with 3% hydrogen peroxide and 1.5% potassium nitrate (n = 41), and the control group using Crest 3D Whitestrips only with 3% hydrogen peroxide (n = 41). Participants attached whitening strips to the teeth' buccal surface for 30 min once daily at home for 28 days continuously. Tooth sensitivity was evaluated using the Schiff score. Tooth color and color change were assessed using a spectrophotometer (CIELAB coordinates L*, a*, b*, ΔE*_ab, and dental whiteness index ΔWI_D) and shade guides (Vita Classical ΔSGU and Vita Bleachedguide ΔSGU), with measurements made at baseline and after 7, 14, 21, and 28 days' use. Levene test, repeated measures ANOVA, post hoc Tukey tests, the Kruskal–Wallis test and the Bonferroni correction method were used for data analysis (α = 5%).

Results

In color differences (ΔE*_ab) and whiteness index (ΔWI_D) analysis, a change of ΔE*_ab ≥ 1.2 or ΔWI_D ≥ 0.72 was considered visually perceptible. Both groups showed clinically significant tooth whitening after 7 days and notable ΔE*_ab and increases in ΔWI_D were observed in both groups (p < 0.05). After 14 days, both groups showed increased brightness (ΔL*) and reduced yellowness (Δb*) (p < 0.05). After 28 days, there was no discernible tooth sensitivity in the experimental group, while there was some obvious tooth sensitivity in the control group. Both groups showed a significant change in tooth color compared to the baseline but there were no significant differences between the two groups.

Conclusion

LESENING whitening strips with 3% hydrogen peroxide and 1.5% potassium nitrate were esthetically effective. Moreover, the LESENING group showed lower tooth sensitivity change than the Crest group.

Clinical Relevance

The use of LESENING whitening strips with 3% hydrogen peroxide and 1.5% potassium nitrate for at-home dental whitening could reduce the risk of dentin hypersensitivity without compromising whitening efficacy.

Trial Registration: ISRCTN registry number: ISRCTN30027746

查看原文本刊更多论文

评价一种新型美白贴片的有效性和牙齿敏感性：一项随机、双盲对照试验。

目的：通过随机对照临床试验，评价一种新型3%过氧化氢+ 1.5%硝酸钾美白贴的牙齿美白效果和牙齿敏感性。材料与方法：96名受试者随机分为两组，实验组使用3%过氧化氢加1.5%硝酸钾的乐宁美白贴片（n = 41），对照组使用3%过氧化氢加佳洁士3D美白贴片（n = 41）。参与者在家中将美白条贴在牙齿颊表面30分钟，连续28天。使用希夫评分评估牙齿敏感性。使用分光光度计（CIELAB坐标L*， a*, b*， ΔE*ab和牙齿白度指数ΔWID）和色度指南（Vita Classical ΔSGU和Vita Bleachedguide ΔSGU）评估牙齿颜色和颜色变化，并在基线和使用7、14、21和28天后进行测量。数据分析采用Levene检验、重复测量方差分析、事后Tukey检验、Kruskal-Wallis检验和Bonferroni校正法（α = 5%）。结果：在色差（ΔE*ab）和白度指数（ΔWID）分析中，ΔE*ab≥1.2或ΔWID≥0.72的变化被认为是视觉可感知的。两组患者术后7 d均有显著的临床牙美白效果，且两组患者的ΔE*ab和ΔWID均有显著升高(p)。结论：3%过氧化氢+ 1.5%硝酸钾的leening美白条具有较好的美观性。此外，LESENING组的牙齿敏感性变化低于佳洁士组。临床意义：使用含有3%过氧化氢和1.5%硝酸钾的LESENING美白条进行家庭牙齿美白可以在不影响美白效果的情况下降低牙本质过敏的风险。试验注册：ISRCTN注册号：ISRCTN30027746。

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来源期刊

Journal of Esthetic and Restorative Dentistry 医学-牙科与口腔外科

CiteScore

6.30

自引率

6.20%

发文量

124

审稿时长

>12 weeks

期刊介绍： The Journal of Esthetic and Restorative Dentistry (JERD) is the longest standing peer-reviewed journal devoted solely to advancing the knowledge and practice of esthetic dentistry. Its goal is to provide the very latest evidence-based information in the realm of contemporary interdisciplinary esthetic dentistry through high quality clinical papers, sound research reports and educational features. The range of topics covered in the journal includes: - Interdisciplinary esthetic concepts - Implants - Conservative adhesive restorations - Tooth Whitening - Prosthodontic materials and techniques - Dental materials - Orthodontic, periodontal and endodontic esthetics - Esthetics related research - Innovations in esthetics