The Value of Using 5T MRI T1ρ and T2 Mapping Sequences in Evaluating Muscle Changes Around Knee Osteoarthritis.

IF 2.8 4区医学 Q3 PHARMACOLOGY & PHARMACY

Dose-Response Pub Date : 2025-12-04 eCollection Date: 2025-10-01 DOI:10.1177/15593258251401945

Min Fu, Zhaohui Yin, Jie Gan, Tianyu Bai, Hu Li, Zudong Yin, Lei Yu

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Abstract

Objective: To explore the value of 5T magnetic resonance imaging (MRI) T1ρ and T2 mapping sequences in evaluating muscle changes around knee osteoarthritis (KOA).

Methods: 50 KOA patients and 36 healthy volunteers underwent knee MRI and peripheral muscle T1ρ/T2 mapping scans, comparing intergroup differences in each muscle's T1ρ/T2 values and analyzing their correlation with KOA severity.

Results: The T1ρ and T2 values of the vastus medialis, vastus lateralis, biceps femoris, medial head of gastrocnemius, lateral head of gastrocnemius, and popliteus in KOA patients were higher than those in healthy volunteers, as well as the T2 values of the sartorius and semimembranosus. The T1ρ value of the vastus medialis is positively correlated with the whole-organ MRI score (WORMS) for the knee. The T2 values of the vastus medialis, sartorius, semimembranosus, popliteus, medial head of gastrocnemius, lateral head of gastrocnemius, biceps femoris and vastus lateralis are also positively correlated with the WORMS for the knee.

Conclusion: The 5T MRI T1ρ and T2 mapping techniques can sensitively and quantitatively evaluate the changes in peri-articular muscles with KOA, providing important references for the clinical diagnosis and treatment of KOA.

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5T MRI T1ρ和T2序列在评估膝关节骨性关节炎周围肌肉变化中的价值。

目的：探讨5T磁共振成像（MRI） T1ρ和T2定位序列在评估膝关节骨性关节炎（KOA）周围肌肉变化中的价值。方法：对50例KOA患者和36名健康志愿者进行膝关节MRI和外周肌肉T1ρ/T2图谱扫描，比较各组间各肌肉T1ρ/T2值的差异，并分析其与KOA严重程度的相关性。结果：KOA患者的股内侧肌、股外侧肌、股二头肌、腓肠肌内侧头、腓肠肌外侧头、腘肌的T1ρ和T2值均高于健康志愿者，缝阔肌和半膜肌的T2值也高于健康志愿者。股内侧肌的T1ρ值与膝关节全器官MRI评分（WORMS）呈正相关。股内侧肌、缝阔肌、半膜肌、腘肌、腓肠肌内侧头、腓肠肌外侧头、股二头肌、股外侧肌的T2值也与膝关节的WORMS呈正相关。结论：5T MRI T1ρ和T2测图技术能灵敏、定量地评价KOA关节周围肌肉的变化，为KOA的临床诊断和治疗提供重要参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dose-Response PHARMACOLOGY & PHARMACY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

4.90

自引率

4.00%

发文量

140

审稿时长

>12 weeks

期刊介绍： Dose-Response is an open access peer-reviewed online journal publishing original findings and commentaries on the occurrence of dose-response relationships across a broad range of disciplines. Particular interest focuses on experimental evidence providing mechanistic understanding of nonlinear dose-response relationships.