{"title":"Listening to the Past, Shaping the Future: A Data-mining Based and Visual Analysis of Five Decades of Gastric Carcinogenesis Research.","authors":"Tai Zhang, Xudong Tang","doi":"10.1186/s12575-025-00316-y","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer remains a major global health concern with approximately one million new cases annually. Despite five decades of extensive research, comprehensive analysis mapping gastric carcinogenesis research evolution and emerging therapeutic frontiers remains limited. This study aims to systematically analyze the intellectual landscape, research trends, and future directions in gastric carcinogenesis research.</p><p><strong>Materials and methods: </strong>We analyzed 11,527 scientific publications on gastric carcinogenesis from 1970-2024 using advanced scientometric tools including CiteSpace and VOSviewer for co-citation analysis, collaboration network mapping, and keyword co-occurrence analysis.</p><p><strong>Results: </strong>Publication output demonstrated exponential growth, peaking at 547 publications in 2022. Asia leads research productivity with China, Japan, and South Korea contributing 37.50% of total publications, while the United States exhibits highest collaborative influence with betweenness centrality of 0.45. Seven distinct research clusters emerged encompassing Helicobacter pylori pathogenesis, molecular mechanisms, precancerous lesions, autoimmune gastritis, and therapeutic interventions. Five emerging trends were identified: stromal microenvironment interactions in carcinogenesis progression, gastric organoid models for disease modeling, artificial intelligence-enhanced endoscopic detection technologies, biomarker development for early diagnosis, and traditional herbal medicine applications for chemoprevention.</p><p><strong>Conclusions: </strong>Research gaps persist in autoimmune gastritis pathways and clinical translation of molecular discoveries. Emerging research directions encompass advanced modeling systems, molecular diagnostics, and technological applications, though their clinical impact remains to be established through future validation studies.</p>","PeriodicalId":8960,"journal":{"name":"Biological Procedures Online","volume":" ","pages":"3"},"PeriodicalIF":4.9000,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12817797/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological Procedures Online","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1186/s12575-025-00316-y","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
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Abstract
Background: Gastric cancer remains a major global health concern with approximately one million new cases annually. Despite five decades of extensive research, comprehensive analysis mapping gastric carcinogenesis research evolution and emerging therapeutic frontiers remains limited. This study aims to systematically analyze the intellectual landscape, research trends, and future directions in gastric carcinogenesis research.
Materials and methods: We analyzed 11,527 scientific publications on gastric carcinogenesis from 1970-2024 using advanced scientometric tools including CiteSpace and VOSviewer for co-citation analysis, collaboration network mapping, and keyword co-occurrence analysis.
Results: Publication output demonstrated exponential growth, peaking at 547 publications in 2022. Asia leads research productivity with China, Japan, and South Korea contributing 37.50% of total publications, while the United States exhibits highest collaborative influence with betweenness centrality of 0.45. Seven distinct research clusters emerged encompassing Helicobacter pylori pathogenesis, molecular mechanisms, precancerous lesions, autoimmune gastritis, and therapeutic interventions. Five emerging trends were identified: stromal microenvironment interactions in carcinogenesis progression, gastric organoid models for disease modeling, artificial intelligence-enhanced endoscopic detection technologies, biomarker development for early diagnosis, and traditional herbal medicine applications for chemoprevention.
Conclusions: Research gaps persist in autoimmune gastritis pathways and clinical translation of molecular discoveries. Emerging research directions encompass advanced modeling systems, molecular diagnostics, and technological applications, though their clinical impact remains to be established through future validation studies.
期刊介绍：
iological Procedures Online publishes articles that improve access to techniques and methods in the medical and biological sciences.
We are also interested in short but important research discoveries, such as new animal disease models.
Topics of interest include, but are not limited to:
Reports of new research techniques and applications of existing techniques
Technical analyses of research techniques and published reports
Validity analyses of research methods and approaches to judging the validity of research reports
Application of common research methods
Reviews of existing techniques
Novel/important product information
Biological Procedures Online places emphasis on multidisciplinary approaches that integrate methodologies from medicine, biology, chemistry, imaging, engineering, bioinformatics, computer science, and systems analysis.
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