77 - Diet-induced obesity and alveolar bne loss: insights form a murine model

Abstract

Background

Childhood/adolescence are critical for craniofacial development. While genetics play a role in the obesity pandemic, sociocultural factors, especially nutrition, are key. High-fat, high-energy diets impact bone health, crucial for orthodontic treatment outcomes.

Objectives

This pilot study evaluated the effects of an obesogenic diet on alveolar bone and femur microarchitecture in growing male Wistar rats.

Methods

Twelve rats were divided into control (standard diet) and experimental (cafeteria diet) groups for eight weeks. Weight, size, abdominal circumference, and glucose levels were monitored. Micro-CT analysis assessed bone microarchitecture.

Results

experimental group showed significant weight gain, increased abdominal circumference, and elevated glucose. Alveolar bone microarchitecture differed significantly; trabecular thickness (Tb.Th) was greater in the experimental group (109.808 ± 8.201 µm vs 94.577 ± 12.943 µm). Femoral head bone showed no differences. No statistical changes were observed in BV/TV, Tb.Th and Tb.Sp of femur.

Conclusions

An obesogenic diet negatively impacts alveolar bone microarchitecture, potentially affecting craniofacial development and orthodontic treatment. Further research is needed to understand the mechanisms and long-term implications. Understanding this relationship is crucial for comprehensive orthodontic care