Evaluating the demographics and complications of North American surgical patients with ossification of the posterior longitudinal ligament

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Clinical Neuroscience Pub Date : 2026-02-01 Epub Date: 2025-12-06 DOI:10.1016/j.jocn.2025.111790

Aaron Phung , Justin Hyde , Justin Azmoodeh , Theodore Quan , Lancelot Benn , Christopher P. Bellaire , Oliver Tannous , Joseph Ferguson , Seyed B Kalantar , David Weiner , Andrew Mo , Fred Mo , Sean Bae , Ala Alshomali , Crisanto L. Macaraeg , Kevin Yoon , Jonathan P. Japa , Mark Ehioghae , Addisu Mesfin

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引用次数: 0

Abstract

Introduction

Ossification of the posterior longitudinal ligament (OPLL) is a hyperostotic spinal condition resulting from progressive endochondral ossification of the posterior longitudinal ligament, leading to spinal canal narrowing and spinal cord compression. Primarily seen in East Asian countries, OPLL has been increasingly recognized in North American cohorts. This study aims to evaluate the demographic characteristics and outcomes of patients undergoing surgery for OPLL in a North American cohort.

Methods

This was a single-center retrospective cohort study of patients with OPLL undergoing surgery between July 2011 and November 2024. Data collected included demographic information, body mass index (BMI), comorbidities, surgical approach, OPLL classification, and K-line measurement. Estimated blood loss (EBL), intra/post-operative complications, length of stay, and disposition status were also recorded. Descriptive statistics and multivariable analyses were conducted with a p value < 0.05 considered to be statistically significant.

Results

In total, 81 patients underwent surgery for OPLL (mean age of 60 years; 50.6 % male). Most of the patients were Black (43 patients, 53.1 %).The mean BMI was 33.1 kg/m². Forty-four patients (54.3 %) had diabetes. Most of the surgeries were elective (88.9 %). The classification of OPLL for the patients were: 31.7 % segmental, 20 % continuous, and 40 % mixed. 73.3 % of the patients had a positive K-line. Surgically, the posterior approach (41 patients, 50.6 %) was more common. A posterior approach was more likely to be utilized for patients with a positive K-line measurement (p = 0.029). Obesity was associated with increased EBL (p = 0.032). Five patients experienced intraoperative complications. The mean length of stay was 6.5 days, and average follow-up was 20.4 months. Three patients (3.7 %) passed post-operatively, and none underwent reoperation.

Conclusion

This study highlights the demographic and clinical characteristics of OPLL in a diverse North American cohort. Surgical management, predominantly via anterior or posterior approaches, was associated with low complication rates and no reoperations during follow-up.

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评估北美手术患者后纵韧带骨化的人口统计学和并发症。

后纵韧带骨化（OPLL）是由后纵韧带进行性软骨内骨化引起的脊柱肥大，导致椎管狭窄和脊髓受压。OPLL主要见于东亚国家，在北美群体中也越来越得到认可。本研究旨在评估北美队列中接受OPLL手术患者的人口学特征和预后。方法：这是一项单中心回顾性队列研究，研究对象为2011年7月至2024年11月期间接受手术的OPLL患者。收集的数据包括人口统计信息、体重指数（BMI）、合并症、手术方式、OPLL分类和k线测量。估计失血量（EBL）、术中/术后并发症、住院时间和处置状态也被记录下来。结果：共有81例OPLL患者接受手术治疗，平均年龄60岁，男性50.6%。黑人居多（43例，53.1%）。平均BMI为33.1 kg/m2。44例（54.3%）有糖尿病。大多数手术是选择性的（88.9%）。OPLL的分类为：31.7%为节段性，20%为连续性，40%为混合性。73.3%的患者k线阳性。手术上，后路入路更为常见（41例，50.6%）。k线测量阳性的患者更可能采用后路入路（p = 0.029）。肥胖与EBL升高相关（p = 0.032）。5例患者出现术中并发症。平均住院时间6.5天，平均随访20.4个月。3例（3.7%）术后顺利通过，无再次手术。结论：本研究强调了北美不同人群中OPLL的人口学和临床特征。手术治疗主要通过前路或后路，并发症发生率低，随访期间无再手术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Neuroscience 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

402

审稿时长

40 days

期刊介绍： This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology. The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.