Bile acids insufficiency links perfluorooctane sulfonate-induced oxidative stress-mediated fatty liver with osteoarthritis

IF 10.6 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Journal of Hazardous Materials Pub Date : 2025-12-08 DOI:10.1016/j.jhazmat.2025.140750

Jialing Yu, Sihan Huang, Jianbin Zhang, Zijian Su, Yiming Chang, Keke Liu, Lu Yang, Huiying Guo, Jinshao Ye, Xujing Liang, Xiaojia Chen, An Hong, Yibo Zhang

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引用次数: 0

Abstract

Perfluoroalkyl substances (PFAS) are ubiquitously distributed and persistent environmental pollutants. Articular injury caused by numerous environmental pollutants has been reported; however, whether and how PFAS damage joints have yet to be determined. Here, we revealed that exposure to perfluorooctane sulfonate (PFOS) caused osteoarthritis (OA) within the zebrafish anal fin. Mechanistically, PFOS induces oxidative stress in the liver, which decreases bile acid synthesis and transport and causes lipid accumulation. Additionally, exposure to PFOS disturbs the gut microbiota, which may further reduce the production of secondary bile acids. This bile acid insufficiency may limit the activation of farnesoid X receptor (FXR) and the downstream glucagon-like peptide 1 receptor (GLP-1R) in chondrocytes and thereby facilitate the development of OA. Furthermore, we found that by scavenging reactive oxygen species (ROS), astaxanthin (AX) significantly reversed PFOS-induced OA and hepatic steatosis. Our findings elucidated the harmful effects and underlying mechanisms of PFOS on articular health and highlighted ROS scavenging as a therapeutic strategy for PFOS-induced OA.

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胆汁酸不足与全氟辛烷磺酸诱导的氧化应激介导的脂肪肝与骨关节炎有关

全氟烷基物质（PFAS）是一种无所不在的持久性环境污染物。许多环境污染物引起的关节损伤已被报道；然而，PFAS是否以及如何损伤关节尚未确定。在这里，我们揭示了暴露于全氟辛烷磺酸（PFOS）会导致斑马鱼肛鳍内的骨关节炎（OA）。从机制上讲，全氟辛烷磺酸会诱导肝脏氧化应激，从而减少胆囊酸的合成和运输，并导致脂质积累。此外，接触全氟辛烷磺酸会扰乱肠道微生物群，这可能进一步减少次生胆汁酸的产生。这种胆汁酸不足可能限制软骨细胞中法脂类X受体（FXR）和下游胰高血糖素样肽1受体（GLP-1R）的激活，从而促进OA的发展。此外，我们发现虾青素（AX）通过清除活性氧（ROS），显著逆转pfos诱导的OA和肝脏脂肪变性。我们的研究结果阐明了全氟辛烷磺酸对关节健康的有害影响及其潜在机制，并强调了活性氧清除作为全氟辛烷磺酸诱导的OA的治疗策略。

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来源期刊

Journal of Hazardous Materials 工程技术-工程：环境

CiteScore

25.40

自引率

5.90%

发文量

3059

审稿时长

58 days

期刊介绍： The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.